About: A structural perspective of RNA recognition by intrinsically disordered proteins

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About: A structural perspective of RNA recognition by intrinsically disordered proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A structural perspective of RNA recognition by intrinsically disordered proteins
Creator	Bahadur, Prasad Basu, Sushmita Ranjit, •
source	Medline; PMC
abstract	Protein-RNA recognition is essential for gene expression and its regulation, which is indispensable for the survival of the living organism at one hand, on the other hand, misregulation of this recognition may lead to their extinction. Polymorphic conformation of both the interacting partners is a characteristic feature of such molecular recognition that promotes the assembly. Many RNA binding proteins (RBP) or regions in them are found to be intrinsically disordered, and this property helps them to play a central role in the regulatory processes. Sequence composition and the length of the flexible linkers between RNA binding domains in RBPs are crucial in making significant contacts with its partner RNA. Polymorphic conformations of RBPs can provide thermodynamic advantage to its binding partner while acting as a chaperone. Prolonged extensions of the disordered regions in RBPs also contribute to the stability of the large cellular machines including ribosome and viral assemblies. The involvement of these disordered regions in most of the significant cellular processes makes RBPs highly associated with various human diseases that arise due to their misregulation.
has issue date	2016-05-26(xsd:dateTime)
bibo:doi	10.1007/s00018-016-2283-1
bibo:pmid	27229125
has license	no-cc
sha1sum (hex)	2a066d13074f224d0078ffe3abbbc042a5a1883b
schema:url	https://doi.org/10.1007/s00018-016-2283-1
resource representing a document's title	A structural perspective of RNA recognition by intrinsically disordered proteins
has PubMed Central identifier	PMC7079799
has PubMed identifier	27229125
schema:publication	Cell Mol Life Sci
resource representing a document's body	covid:2a066d13074f224d0078ffe3abbbc042a5a1883b#body_text
is schema:about of	named entity 'ESSENTIAL' named entity 'LIVING ORGANISM' named entity 'ADVANTAGE' named entity 'HAND' named entity 'LENGTH' named entity 'FLEXIBLE' named entity 'INVOLVEMENT' named entity 'RNA BINDING' named entity 'BINDING' named entity 'CONTRIBUTE ' named entity 'PROTEIN-RNA' named entity 'INCLUDING' named entity 'PROPERTY' named entity 'FEATURE' named entity 'CONFORMATION' named entity 'binding' named entity 'Many' named entity 'organism' named entity 'flexible' named entity 'regions' named entity 'disordered' named entity 'cellular processes' named entity 'cellular' named entity 'expression' named entity 'FOUND' named entity 'CHARACTERISTIC' named entity 'CELLULAR' named entity 'PROLONGED' named entity 'REGULATION' named entity 'PROCESSES' named entity 'INTRINSICALLY DISORDERED PROTEINS' named entity 'PERSPECTIVE' named entity 'DISORDERED' named entity 'RNA BINDING PROTEINS' named entity 'THESE' named entity 'PLAY' named entity 'HIGHLY' named entity 'SEQUENCE COMPOSITION' named entity 'CELLULAR PROCESSES' named entity 'REGULATORY' named entity 'PARTNERS' named entity 'RECOGNITION' named entity 'PROVIDE' named entity 'GENE EXPRESSION' named entity 'LARGE' named entity 'RNA' named entity 'ASSOCIATED WITH' named entity 'RIBOSOME' named entity 'RECOGNITION' named entity 'STRUCTURAL' named entity 'HELPS' named entity 'THEIR' named entity 'STABILITY' named entity 'CONTACTS' named entity 'CHAPERONE' named entity 'HUMAN DISEASES' named entity 'ITS' named entity 'REGIONS' named entity 'SURVIVAL' named entity 'MOLECULAR RECOGNITION' named entity 'INDISPENSABLE' named entity 'INTERACTING' named entity 'DUE TO' named entity 'RNA' named entity 'SIGNIFICANT' named entity 'POLYMORPHIC' named entity 'EXTENSIONS' named entity 'EXTINCTION' named entity 'LEAD' named entity 'VIRAL' named entity 'IS A' named entity 'ASSEMBLY' named entity 'PARTNER' named entity 'MACHINES' named entity 'THERMODYNAMIC' named entity 'CENTRAL' named entity 'ROLE' named entity 'VARIOUS' covid:arg/2a066d13074f224d0078ffe3abbbc042a5a1883b

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