About: Using Morpholinos to Control Gene Expression

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Using Morpholinos to Control Gene Expression
Creator	Moulton, Jon
Source	PMC
abstract	Morpholino oligonucleotides are stable, uncharged, water‐soluble molecules used to block complementary sequences of RNA, preventing processing, read‐through, or protein binding at those sites. Morpholinos are typically used to block translation of mRNA and to block splicing of pre‐mRNA, though they can block other interactions between biological macromolecules and RNA. Morpholinos are effective, specific, and lack non‐antisense effects. They work in any cell that transcribes and translates RNA, but must be delivered into the nuclear/cytosolic compartment to be effective. Morpholinos form stable base pairs with complementary nucleic acid sequences but apparently do not bind to proteins to a significant extent. They are not recognized by any proteins and do not undergo protein‐mediated catalysis—nor do they mediate RNA cleavage by RNase H or the RISC complex. This work focuses on techniques and background for using Morpholinos. © 2017 by John Wiley & Sons, Inc.
has issue date	2017-03-02(xsd:dateTime)
bibo:doi	10.1002/cpnc.21
bibo:pmid	28252184
has license	no-cc
sha1sum (hex)	2a024520f269564c4821cbe9b09d06896e904276
schema:url	https://doi.org/10.1002/cpnc.21
resource representing a document's title	Using Morpholinos to Control Gene Expression
has PubMed Central identifier	PMC7162182
has PubMed identifier	28252184
schema:publication	Curr Protoc Nucleic Acid Chem
resource representing a document's body	covid:2a024520f269564c4821cbe9b09d06896e904276#body_text
is schema:about of	named entity 'oligonucleotides' named entity 'cytosolic' named entity 'Gene Expression' named entity 'NUCLEAR' named entity 'CATALYSIS' named entity 'USED' named entity 'INTERACTIONS' named entity 'PROTEIN' named entity 'delivered' named entity 'mRNA' named entity 'extent' named entity 'RISC' named entity 'protein binding' named entity 'antisense' named entity 'RNA' named entity 'RISC complex' named entity 'water-soluble' named entity 'cytosolic' named entity 'splicing' named entity 'Control Gene Expression' named entity 'nitrogen atom' named entity 'Morpholinos' named entity 'Morpholino' named entity 'phosphates' named entity 'algorithm' named entity 'oligo' named entity 'egfl7' named entity 'trial and error' named entity 'Morpholinos' named entity 'A-form' named entity 'Morpholinos' named entity 'Morpholino' named entity 'cell-penetrating peptides' named entity 'Morpholino' named entity 'nucleases' named entity 'Morpholino' named entity 'phenotype' named entity 'Morpholino' named entity 'Morpholinos' named entity 'time scales' named entity 'exon' named entity 'oligo' named entity '37°C' named entity 'mRNA' named entity '10.0' named entity 'radionuclides' named entity 'PCR' named entity 'exons' named entity 'mRNA' named entity 'exon' named entity 'immunoblotting' named entity 'exon' named entity 'conjugated' named entity 'Morpholino' named entity 'Morpholinos' named entity 'cleavage' named entity 'Gene Tools' named entity 'Morpholinos' named entity 'intronic' named entity 'moiety' named entity 'spinal muscular atrophy' named entity 'qPCR' named entity 'Morpholinos' named entity 'intramuscular injection' named entity 'neutral pH' named entity 'Morpholinos' named entity 'oligo' named entity 'target site' named entity 'coding sequence' named entity 'mice' named entity 'oligo' named entity 'primers' named entity 'quartz' named entity 'Morpholino' named entity 'nucleus' named entity 'intron' named entity 'oligo' named entity 'phosphate' named entity 'morpholine' named entity 'Morpholino' named entity 'nonionic'

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