About: Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development

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About: Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development
Creator	Qin, Ling Sheng, Hui Zhang, Ge Chan, C Wang, Y Xiang, Yi Lee, K Leung, K Wang, H Cheung, W Fu, Hong Hoi, Wing Man, Kwong Sui, Kwok Wai, Chun
Source	Medline; PMC
abstract	BACKGROUND: Increased bone marrow lipid deposition in steroid-associated osteonecrosis (ON) implies that abnormalities in fat metabolism play an important role in ON development. The increase in lipid deposition might be explained by elevated adipogenesis of marrow mesenchymal stem cells (MSCs). However, it remains unclear whether there is a close association between elevated adipogenesis and steroid-associated ON development. OBJECTIVE: The present study was designed to test the hypothesis that there might be a close association between elevated adipogenesis and steroid-associated ON development. METHODS: ON rabbit model was induced based on our established protocol. Dynamic-MRI was employed for local intra-osseous perfusion evaluation in bilateral femora. Two weeks after induction, bone marrow was harvested for evaluating the ability of adipogenic differentiation of marrow MSCs at both cellular and mRNA level involving adipogenesis-related gene peroxisome proliferator-activated receptor gamma2 (PPARγ2). The bilateral femora were dissected for examining marrow lipid deposition by quantifying fat cell number, fat cell size, lipid deposition area and ON lesions. For investigating association among adipogenesis, lipid deposition and perfusion function with regard to ON occurrence, the rabbits were divided into ON(+ )(with at least one ON lesion) group and ON(- )(without ON lesion) group. For investigating association among adipogenesis, lipid deposition and perfusion function with regard to ON extension, the ON(+ )rabbits were further divided into sub-single-lesion group (SON group: with one ON lesion) and sub-multiple-lesion group (MON group: with more than one ON lesion). RESULTS: Local intra-osseous perfusion index was found lower in either ON(+ )or MON group when compared to either ON(- )or SON group, whereas the marrow fat cells number and area were much larger in either ON(+ )or MON group as compared with ON(- )and SON group. The adipogenic differentiation ability of MSCs and PPARγ2 expression in either ON(+ )or MON group were elevated significantly as compared with either ON(- )or SON group. CONCLUSION: These findings support our hypothesis that there is a close association between elevated adipogenesis and steroid-associated osteonecrosis development.
has issue date	2007-10-15(xsd:dateTime)
bibo:doi	10.1186/1749-799x-2-15
bibo:pmid	17937789
has license	cc-by
sha1sum (hex)	296e24d0dc3c17633eeffea57bd23e968a1c8a5e
schema:url	https://doi.org/10.1186/1749-799x-2-15
resource representing a document's title	Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development
has PubMed Central identifier	PMC2146995
has PubMed identifier	17937789
schema:publication	J Orthop Surg
resource representing a document's body	covid:296e24d0dc3c17633eeffea57bd23e968a1c8a5e#body_text
is schema:about of	named entity 'development' named entity 'mesenchymal stem cells' named entity 'adipogenesis' named entity 'mesenchymal stem cells' named entity 'STEROID' named entity 'ELEVATED' named entity 'ADIPOGENESIS' named entity 'DEVELOPMENT' named entity 'UNCLEAR' named entity 'LIPID DEPOSITION' named entity 'BONE MARROW' named entity 'BACKGROUND' named entity 'ASSOCIATION' named entity 'MARROW' named entity 'ASSOCIATED' named entity 'MESENCHYMAL STEM CELLS' named entity 'MARROW' named entity 'ADIPOGENESIS' named entity 'ELEVATED' named entity 'OSTEONECROSIS' named entity 'CLOSE' named entity 'STEROID' named entity 'ASSOCIATED' named entity 'IMPORTANT' named entity 'INCREASED' named entity 'MIGHT BE' named entity 'IS A' named entity 'EXPLAINED' named entity 'MESENCHYMAL STEM CELLS' named entity 'EARLY' named entity 'FAT METABOLISM' named entity 'ROLE' named entity 'ABNORMALITIES' named entity 'OSTEONECROSIS' named entity 'DEVELOPMENT' named entity 'INCREASE' named entity 'PLAY' covid:arg/296e24d0dc3c17633eeffea57bd23e968a1c8a5e named entity 'MSCs' named entity 'elevated' named entity 'adipogenesis' named entity 'osteoarthritis' named entity 'Histopathological' named entity 'mesenchymal stem cells' named entity 'fat cells' named entity 'fat' named entity 'LPS' named entity 'adipogenic' named entity 'ROIs' named entity 'Statistical significance' named entity 'close' named entity 'intraosseous' named entity 'densitometer' named entity 'lipid' named entity 'MSCs' named entity 'adipogenesis' named entity 'steroid' named entity 'SPSS Inc.' named entity 'osteonecrosis' named entity 'blood sinusoids' named entity 'adipogenesis' named entity 'Perfusion' named entity 'fat cells' named entity 'colony-forming unit' named entity 'fatty tissue' named entity 'proximal femur' named entity 'fat cells'

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