About: Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events
Creator	Smole, Sandra Luban, Jeremy Carter, Amber Gladden-Young, Adrianne Gnirke, Andreas Lin, Aaron Madoff, Lawrence Myhrvold, Cameron Park, Daniel Ryan, Edward Sabeti, Pardis Schaffner, Stephen Siddle, Katherine Tomkins-Tinch, Christopher Hanage, William Branda, John Larocque, Regina Adams, Gordon Affiliations, ⍖ Anahtar, Melis Baggett, Travis Bauer, Matthew Brown, Catherine Burns, Meagan Cerrato, Felecia Chaluvadi, Sushma Chapman, Sinead Cusick, Caroline Deruff, Katherine Farhat, Maha Fink, Timelia Flowers, Katelyn Gaeta, Jessie Gallagher, Glen Harris, Jason Hooper, David Kemball, Molly Krasilnikova, Lydia Lagerborg, Kim Lemieux, Jacob Lieberman, Tami Macinnis, Bronwyn Loreth, Christine Neumann, Anna Normandin, Erica O'connell, James Philippakis, Anthony Pierce, Virginia Reilly, Steven Rosenberg, Eric Rudy, Melissa Shaw, Bennett Slater, Damien Turbett, Sarah
Source	MedRxiv
abstract	SARS-CoV-2 has caused a severe, ongoing outbreak of COVID-19 in Massachusetts with 111,070 confirmed cases and 8,433 deaths as of August 1, 2020. To investigate the introduction, spread, and epidemiology of COVID-19 in the Boston area, we sequenced and analyzed 772 complete SARS-CoV-2 genomes from the region, including nearly all confirmed cases within the first week of the epidemic and hundreds of cases from major outbreaks at a conference, a nursing facility, and among homeless shelter guests and staff. The data reveal over 80 introductions into the Boston area, predominantly from elsewhere in the United States and Europe. We studied two superspreading events covered by the data, events that led to very different outcomes because of the timing and populations involved. One produced rapid spread in a vulnerable population but little onward transmission, while the other was a major contributor to sustained community transmission, including outbreaks in homeless populations, and was exported to several other domestic and international sites. The same two events differed significantly in the number of new mutations seen, raising the possibility that SARS-CoV-2 superspreading might encompass disparate transmission dynamics. Our results highlight the failure of measures to prevent importation into MA early in the outbreak, underscore the role of superspreading in amplifying an outbreak in a major urban area, and lay a foundation for contact tracing informed by genetic data.
has issue date	2020-08-25(xsd:dateTime)
bibo:doi	10.1101/2020.08.23.20178236
has license	medrxiv
sha1sum (hex)	291be405cc948141ab3b1ac57f3ec603f5445048
schema:url	https://doi.org/10.1101/2020.08.23.20178236
resource representing a document's title	Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events
resource representing a document's body	covid:291be405cc948141ab3b1ac57f3ec603f5445048#body_text
is schema:about of	named entity 'REVEAL' named entity 'DIFFERENT' named entity 'COVID-19' named entity 'RESULTS' named entity '111' named entity 'SUSTAINED' named entity 'SARS-CoV-2' named entity 'ongoing outbreak' named entity 'COVID-19' named entity 'genetic data' named entity 'superspreading events' named entity 'Boston' named entity 'Europe' named entity 'nursing facility' named entity 'Phylogenetic analysis' named entity 'tidyverse' named entity 'distance matrix' named entity 'allele' named entity 'genome' named entity 'random sample' named entity 'genome sequences' named entity 'medRxiv' named entity 'SNF' named entity 'COVID-19' named entity 'genome sequences' named entity 'infection control' named entity 'SARS-CoV-2' named entity 'viruses' named entity 'summary statistics' named entity 'phylogenetic analysis' named entity 'genomes sequenced' named entity 'CC-BY-ND'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software