About: Mannose-Binding Lectin Contributes to Deleterious Inflammatory Response in Pandemic H1N1 and Avian H9N2 Infection

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About: Mannose-Binding Lectin Contributes to Deleterious Inflammatory Response in Pandemic H1N1 and Avian H9N2 Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mannose-Binding Lectin Contributes to Deleterious Inflammatory Response in Pandemic H1N1 and Avian H9N2 Infection
Creator	Liu, Ming Tu, Wenwei Law, Helen Guan, Jing Han, Yan Mao, Huawei Peiris, J Lam, Kwok Chong, Wai Lau, Yu Ling, Man Takahashi, K
Source	PMC
abstract	Background. Mannose-binding lectin (MBL) is a pattern-recognition molecule, which functions as a first line of host defense. Pandemic H1N1 (pdmH1N1) influenza A virus caused massive infection in 2009 and currently circulates worldwide. Avian influenza A H9N2 (H9N2/G1) virus has infected humans and has the potential to be the next pandemic virus. Antiviral function and immunomodulatory role of MBL in pdmH1N1 and H9N2/G1 virus infection have not been investigated. Methods. In this study, MBL wild-type (WT) and MBL knockout (KO) murine models were used to examine the role of MBL in pdmH1N1 and H9N2/G1 virus infection. Results. Our study demonstrated that in vitro, MBL binds to pdmH1N1 and H9N2/G1 viruses, likely via the carbohydrate recognition domain of MBL. Wild-type mice developed more severe disease, as evidenced by a greater weight loss than MBL KO mice during influenza virus infection. Furthermore, MBL WT mice had enhanced production of proinflammatory cytokines and chemokines compared with MBL KO mice, suggesting that MBL could upregulate inflammatory responses that may potentially worsen pdmH1N1 and H9N2/G1 virus infections. Conclusions. Our study provided the first in vivo evidence that MBL may be a risk factor during pdmH1N1 and H9N2/G1 infection by upregulating proinflammatory response.
has issue date	2011-11-11(xsd:dateTime)
bibo:doi	10.1093/infdis/jir691
bibo:pmid	22080095
has license	bronze-oa
sha1sum (hex)	2914c6a1f8f0bb25727bdfcd9a8a7b42d424d521
schema:url	https://doi.org/10.1093/infdis/jir691
resource representing a document's title	Mannose-Binding Lectin Contributes to Deleterious Inflammatory Response in Pandemic H1N1 and Avian H9N2 Infection
has PubMed Central identifier	PMC3242741
has PubMed identifier	22080095
schema:publication	The Journal of Infectious Diseases
resource representing a document's body	covid:2914c6a1f8f0bb25727bdfcd9a8a7b42d424d521#body_text
is schema:about of	named entity 'H1N1' named entity 'AVIAN INFLUENZA A' named entity 'FUNCTIONS' named entity 'VIRUS INFECTION' named entity 'A PATTERN' named entity 'LINE' named entity 'Antiviral' named entity 'Infection' named entity 'Pandemic' named entity 'INFLAMMATORY RESPONSE' named entity 'AVIAN' named entity 'HOST DEFENSE' named entity 'MBL' named entity 'MASSIVE' named entity 'INFECTION' named entity 'MANNOSE-BINDING LECTIN' named entity 'IS A' named entity 'PANDEMIC' named entity 'VIRUS' named entity 'INVESTIGATED' named entity 'POTENTIAL' named entity 'HAVE' named entity 'H1N1' named entity 'PANDEMIC' named entity 'ANTIVIRAL' named entity 'IMMUNOMODULATORY' named entity 'CAUSED' named entity 'INFLUENZA A VIRUS' named entity 'MANNOSE-BINDING LECTIN' named entity 'BACKGROUND' named entity 'CURRENTLY' named entity 'INFECTED' named entity 'ROLE' named entity 'INFECTION' named entity 'RECOGNITION' named entity 'HUMANS' named entity 'FUNCTION' named entity 'WORLDWIDE' named entity 'CIRCULATES' named entity 'MOLECULE' covid:arg/2914c6a1f8f0bb25727bdfcd9a8a7b42d424d521 named entity 'lectin' named entity 'molecule' named entity 'H5N1' named entity 'lung' named entity 'MBL' named entity 'morbidity' named entity 'tissue culture' named entity 'MBL' named entity 'H9N2' named entity 'infection' named entity 'Toll-like receptors' named entity 'infected' named entity 'virus' named entity 'virus infection' named entity 'Mannose-binding lectin' named entity 'infection' named entity 'H9N2' named entity 'host defense' named entity 'Inflammatory Response' named entity 'pathogens' named entity 'centrifuged' named entity 'IL-6' named entity 'inflammation' named entity 'lung' named entity 'virus' named entity 'virus' named entity 'lung inflammation' named entity 'IL-6' named entity 'KO mice'

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