About: Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms

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About: Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms
Creator	Rosenberg, Madelaine Turbide, Claire Beauchemina, Nicole Mccuaig, Kimberly Ncdellec, Patrick
Source	Elsevier; Medline; PMC
abstract	Abstract The biliary glycoprotein (BGP)-encoding gene is a member of the human carcinoembryonic antigen (CEA) gene family. We have now cloned several mouse Bgp cDNAs from an outbred CDR-1 mouse colon cDNA library, as well as by reverse transcription-PCR amplification of colon RNA. The distinguishing features of the deduced Bgp protein isoforms are found in the two divergent N-terminal domains, the highly conserved internal C2-set immunoglobulin domains, and an intracytoplasmic domain of either 10 or 73 amino acids (aa). The cDNA structures suggest that these mRNAs are produced through alternative splicing of a Bgp gene and the usage of multiple transcriptional terminators. The Bgp deduced aa sequences are highly homologous to several well characterized rat hepatocyte proteins such as the cell CAM105/ecto-ATPase/ppl20/HA4 proteins. Oligodeoxyribonucleotide probes representing the various cDNA isoform domains revealed predominant transcripts of 1.8, 3.1 and 4.0 kb on Northern analyses of mouse colon RNA; some of these bands are actually composed of several co-migrating transcripts. The transcripts encoding the long intracytoplasmic-tailed Bgp proteins are expressed at one-tenth the relative abundance of the shorter-tailed species. We have previously demonstrated that several mouse Bgp cDNAs, when transfected into eukaryotic cells, express BGP proteins at the cell surface and function in vitro as cell adhesion molecules, much like their human and rat counterparts. The expression of the many Bgp isoforms at the surface of epithelial cells, such as colon, suggests that these proteins play a determinant role, through self- or heterologous contact, in renewal and/or differentiation of their epithelia.
has issue date	1993-05-30(xsd:dateTime)
bibo:doi	10.1016/0378-1119(93)90716-g
bibo:pmid	8500759
has license	els-covid
sha1sum (hex)	28f87ecceb690e637ce9ac9135f11a6480f22f16
schema:url	https://doi.org/10.1016/0378-1119%2893%2990716-g
resource representing a document's title	Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms
has PubMed Central identifier	PMC7131619
has PubMed identifier	8500759
schema:publication	Gene
resource representing a document's body	covid:28f87ecceb690e637ce9ac9135f11a6480f22f16#body_text
is schema:about of	named entity 'ADHESION MOLECULE' named entity 'IS A' named entity 'EITHER' named entity 'EPITHELIAL CELLS' named entity 'GENE' named entity '1.8' named entity 'ENCODING' named entity 'MOUSE' named entity 'EXPRESSED' named entity 'TRANSCRIPTIONAL' named entity 'HOMOLOGOUS' named entity 'PROTEIN ISOFORMS' named entity 'EXPRESS' named entity 'CELL SURFACE' named entity 'THE CELL' named entity 'COMPOSED OF' named entity 'COLON' named entity 'TRANSCRIPTS' named entity 'EUKARYOTIC CELLS' named entity 'CHARACTERIZED' named entity 'ISOFORM' named entity 'DETERMINANT' named entity 'N-TERMINAL ' named entity 'cDNAs' named entity 'proteins' named entity 'expressed' named entity 'structures' named entity 'multiple' named entity 'cDNAs' named entity 'surface' named entity 'transcripts' named entity 'receptor' named entity 'ISOFORMS' covid:arg/28f87ecceb690e637ce9ac9135f11a6480f22f16 named entity 'CONSERVED' named entity 'MULTIPLE' named entity 'SELF' named entity 'PROTEINS' named entity 'IMMUNOGLOBULIN DOMAINS' named entity 'TENTH' named entity 'RAT' named entity 'SET' named entity 'FAMILY MEMBER' named entity 'GENE FAMILY' named entity 'VIRUS RECEPTOR' named entity 'BILIARY' named entity 'MOUSE HEPATITIS VIRUS' named entity 'VARIOUS' named entity 'HUMAN' named entity 'IN VITRO' named entity 'TAILED' named entity 'THEIR' named entity 'USAGE' named entity 'DISTINGUISHING' named entity 'HETEROLOGOUS' named entity 'RNA' named entity 'FUNCTION' named entity 'CARCINOEMBRYONIC ANTIGEN' named entity 'ISOFORMS' named entity 'LIKE' named entity 'DEMONSTRATED' named entity 'ATPASE' named entity 'MEMBER OF' named entity 'CELL ADHESION MOLECULES' named entity 'MOUSE COLON' named entity 'LONG' named entity 'POLYMERASE' named entity 'GENE' named entity 'CHAIN' named entity 'MOUSE COLON' named entity 'AMPLIFICATION' named entity 'REVERSE TRANSCRIPTION' named entity 'BGP' named entity 'EXPRESSION' named entity 'DOMAIN' named entity 'SPECIES' named entity 'HAVE'

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