About: Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19

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About: Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19
Creator	Alexandre Antunes De Brito, Carlos Cavalcanti, Góes Falcão, Melissa Filho, Filgueiras Menezes, Nivaldo Pamplona, Luciano
Source	Medline; PMC; WHO
abstract	Hydroxychloroquine (HCQ) has been used for the treatment of novel coronavirus disease (COVID-19) cases. However, evidence of efficacy remains limited, and adverse events can be associated with its use. Here, we report a case of a patient with severe COVID-19 who, after being administered HCQ, exhibited a 10-fold increase in serum levels of transaminases, followed by a rapid decrease after HCQ was withdrawn. Considering the significantly increased use of HCQ during the COVID-19 pandemic, this case alerts us to the potential for HCQ to be associated with hepatotoxicity and the need to monitor liver function during HCQ therapy.
has issue date	2020-04-17(xsd:dateTime)
bibo:doi	10.4269/ajtmh.20-0276
bibo:pmid	32314698
has license	cc-by
sha1sum (hex)	2865f9a0709dc493cb225458890337bd3e173e84
schema:url	https://doi.org/10.4269/ajtmh.20-0276
resource representing a document's title	Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19
has PubMed Central identifier	PMC7253107
has PubMed identifier	32314698
schema:publication	Am J Trop Med Hyg
resource representing a document's body	covid:2865f9a0709dc493cb225458890337bd3e173e84#body_text
is schema:about of	named entity 'levels' named entity 'HEPATOTOXICITY' named entity 'ADMINISTERED' named entity 'ITS' named entity 'CORONAVIRUS DISEASE' named entity 'FOLLOWED BY' named entity 'MONITOR' named entity 'patient' named entity 'COVID-19' named entity 'Hydroxychloroquine' named entity 'HCQ' named entity 'HCQ' named entity 'COVID' named entity 'Hepatotoxicity' named entity 'Hydroxychloroquine' named entity 'antimalarial drugs' named entity 'HCQ' named entity 'ophthalmological' named entity 'C-reactive protein' named entity 'case report' named entity 'ICUs' named entity 'HCQ' named entity 'Hepatic dysfunction' named entity 'hepatotoxicity' named entity 'COVID' named entity 'increase in transaminases' named entity 'hemoglobin' named entity 'COVID' named entity 'liver damage' named entity 'oxygen saturation' named entity 'COVID' named entity 'kidney function' named entity 'COVID-19 pandemic' named entity 'D-dimer' named entity 'coronavirus disease' named entity 'Wuhan' named entity 'hematological' named entity 'liver enzymes' named entity 'mechanical ventilation' named entity 'RT-PCR' named entity 'hepatic' named entity 'April 12' named entity 'fever' named entity 'HCQ' named entity 'liver transplant' named entity 'severe acute respiratory syndrome' named entity 'liver enzymes' named entity 'duplex ultrasound' named entity 'diarrhea' named entity 'systemic lupus erythematosus' named entity 'liver enzymes' named entity 'vomiting' named entity 'liver enzymes' named entity 'viral hepatitis' named entity 'AST' named entity 'hydroxychloroquine' named entity 'HCQ' named entity 'HCQ' named entity 'rheumatological' named entity 'COVID' named entity 'drug withdrawal' named entity 'fulminant hepatitis' named entity 'synergistic effect' named entity 'drug-induced hepatitis' named entity 'ICU' named entity 'malaria prophylaxis' named entity 'neurological' named entity 'fever' named entity 'HCQ' named entity 'HCQ' named entity 'critically ill' named entity 'nasal swab' named entity 'HCQ' named entity 'Brasilia' named entity 'COVID' named entity 'porphyria cutanea tarda'

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