About: Manipulation of autophagy by (+) RNA viruses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Manipulation of autophagy by (+) RNA viruses
Creator	Sanyal, Sumana Wong, Ho
Source	Elsevier; Medline; PMC
abstract	Abstract Autophagy is an evolutionarily conserved process central to host metabolism. Among its major functions are conservation of energy during starvation, recycling organelles, and turnover of long-lived proteins. Besides, autophagy plays a critical role in removing intracellular pathogens and very likely represents a primordial intrinsic cellular defence mechanism. More recent findings indicate that it has not only retained its ability to degrade intracellular pathogens, but also functions to augment and fine tune antiviral immune responses. Interestingly, viruses have also co-evolved strategies to manipulate this pathway and use it to their advantage. Particularly intriguing is infection-dependent activation of autophagy with positive stranded (+)RNA virus infections, which benefit from the pathway without succumbing to lysosomal degradation. In this review we summarise recent data on viral manipulation of autophagy, with a particular emphasis on +RNA viruses and highlight key unanswered questions in the field that we believe merit further attention.
has issue date	2020-05-31(xsd:dateTime)
bibo:doi	10.1016/j.semcdb.2019.07.013
bibo:pmid	31382014
has license	els-covid
sha1sum (hex)	28437fde7d8fcc4d4440d3b342815cb5956bd7ad
schema:url	https://doi.org/10.1016/j.semcdb.2019.07.013
resource representing a document's title	Manipulation of autophagy by (+) RNA viruses
has PubMed Central identifier	PMC7102625
has PubMed identifier	31382014
schema:publication	Seminars in Cell & Developmental Biology
resource representing a document's body	covid:28437fde7d8fcc4d4440d3b342815cb5956bd7ad#body_text
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