About: Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia

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About: Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia
Creator	Burdet, Charles Houhou-Fidouh, Nadhira Lescure, François-Xavier Timsit, Jean-François Visseaux, Benoit Voiriot, Guillaume Yazdanpanah, Yazdan Armand-Lefèvre, Laurence Cohen, Johana Morbieu, Caroline Mourvillier, Bruno Neuville, Mathilde Radjou, Aguila Ruckly, Stephane Smonig, Roland Soubirou, Jean-Francois Nguyen, Liem, Binh
Source	PMC
abstract	BACKGROUND: Multiplex polymerase chain reaction (mPCR) enables recovery of viruses from airways of patients with community-acquired pneumonia (CAP), although their clinical impact remains uncertain. METHODS: Among consecutive adult patients who had undergone a mPCR within 72 hours following their admission to one intensive care unit (ICU), we retrospectively included those with a final diagnosis of CAP. Four etiology groups were clustered: bacterial, viral, mixed (viral-bacterial) and no etiology. A composite criterion of complicated course (hospital death or mechanical ventilation > 7 days) was used. A subgroup analysis compared patients with bacterial and viral-bacterial CAP matched on the bacterial pathogens. RESULTS: Among 174 patients (132 men [76 %], age 63 [53–75] years, SAPSII 38 [27;55], median PSI score 106 [78;130]), bacterial, viral, mixed and no etiology groups gathered 46 (26 %), 53 (31 %), 45 (26 %) and 30 (17 %) patients, respectively. Virus-infected patients displayed a high creatine kinase serum level, a low platelet count, and a trend toward more frequent alveolar-interstitial infiltrates. A complicated course was more frequent in the mixed group (31/45, 69 %), as compared to bacterial (18/46, 39 %), viral (15/53, 28 %) and no etiology (12/30, 40 %) groups (p < 0.01). In multivariate analysis, the mixed (viral-bacterial) infection was independently associated with complicated course (reference: bacterial pneumonia; OR, 3.58; CI 95 %, 1.16–11; p = 0.03). The subgroup analysis of bacteria-matched patients confirmed these findings. CONCLUSIONS: Viral-bacterial coinfection during severe CAP in adults is associated with an impaired presentation and a complicated course. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13054-016-1517-9) contains supplementary material, which is available to authorized users.
has issue date	2016-10-25(xsd:dateTime)
bibo:doi	10.1186/s13054-016-1517-9
bibo:pmid	27852281
has license	cc-by
sha1sum (hex)	281520c659ef5b7b5561307d5a91a00526e994f3
schema:url	https://doi.org/10.1186/s13054-016-1517-9
resource representing a document's title	Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia
has PubMed Central identifier	PMC5112669
has PubMed identifier	27852281
schema:publication	Crit Care
resource representing a document's body	covid:281520c659ef5b7b5561307d5a91a00526e994f3#body_text
is schema:about of	named entity 'COINFECTION' named entity 'VIRAL-' named entity 'etiology' named entity 'polymerase' named entity 'bacterial pathogens' named entity '7 days' named entity 'community-acquired pneumonia' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'GROUPS' named entity 'PATIENTS' named entity 'INCLUDED' named entity 'DAYS' named entity 'CLINICAL' named entity 'COMPOSITE' named entity 'VIRAL' named entity 'BACKGROUND' named entity 'IMPACT' named entity 'UNCERTAIN' named entity 'FINAL DIAGNOSIS' named entity 'ADULT' named entity 'MIXED' named entity 'MULTIPLEX POLYMERASE CHAIN REACTION' named entity '72 HOURS' named entity 'ETIOLOGY' named entity 'MATCHED' named entity 'THEIR' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'VIRUSES' named entity 'SEVERE' named entity 'PRESENTATION' named entity 'CLUSTERED' named entity 'RECOVERY' named entity 'ENABLES' named entity 'ADMISSION' named entity 'COURSE' named entity 'FOLLOWING' named entity 'PROGNOSIS' named entity 'MECHANICAL VENTILATION' named entity 'BACTERIAL PATHOGENS' named entity 'BACTERIAL' named entity 'CONSECUTIVE' named entity 'CRITERION' named entity 'DEATH' named entity 'METHODS' named entity 'COMPLICATED' named entity 'INTENSIVE CARE UNIT' named entity 'CAP' named entity 'BACTERIAL' named entity 'USED' named entity 'COMPARED' named entity 'SUBGROUP ANALYSIS' named entity 'AIRWAYS' covid:arg/281520c659ef5b7b5561307d5a91a00526e994f3 named entity 'compared' named entity 'patients' named entity 'airways' named entity 'bacterial' named entity 'matched' named entity 'community-acquired pneumonia' named entity 'remains' named entity 'viruses' named entity 'severe' named entity 'polymerase chain reaction' named entity 'mechanical ventilation'

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