About: Acute respiratory failure in immunocompromised adults

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Acute respiratory failure in immunocompromised adults
Creator	Azoulay, Elie Lemiale, Virginie Demoule, Alexandre Kouatchet, Achille Mokart, Djamel Assistance, Publique Hôpitaux,
source	Elsevier; Medline; PMC
abstract	Acute respiratory failure occurs in up to half of patients with haematological malignancies and 15% of those with solid tumours or solid organ transplantation. Mortality remains high. Factors associated with mortality include a need for invasive mechanical ventilation, organ dysfunction, older age, frailty or poor performance status, delayed intensive care unit admission, and acute respiratory failure due to an invasive fungal infection or unknown cause. In addition to appropriate antibacterial therapy, initial clinical management aims to restore oxygenation and predict the most probable cause based on variables related to the underlying disease, acute respiratory failure characteristics, and radiographic findings. The cause of acute respiratory failure must then be confirmed using the most efficient, least invasive, and safest diagnostic tests. In patients with acute respiratory failure of undetermined cause, a standardised diagnostic investigation should be done immediately at admission before deciding whether to perform more invasive diagnostic procedures or to start empirical treatments. Collaborative and multidisciplinary clinical and research networks are crucial to improve our understanding of disease pathogenesis and causation and to develop less invasive diagnostic strategies and more targeted treatment options.
has issue date	2018-12-07(xsd:dateTime)
bibo:doi	10.1016/s2213-2600(18)30345-x
bibo:pmid	30529232
has license	no-cc
sha1sum (hex)	280ba6db75a0b1d4c2189558f0bd11e379660954
schema:url	https://doi.org/10.1016/s2213-2600%2818%2930345-x
resource representing a document's title	Acute respiratory failure in immunocompromised adults
has PubMed Central identifier	PMC7185453
has PubMed identifier	30529232
schema:publication	Lancet Respir Med
resource representing a document's body	covid:280ba6db75a0b1d4c2189558f0bd11e379660954#body_text
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