About: Binding of the SARS-CoV-2 Spike Protein to Glycans

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Binding of the SARS-CoV-2 Spike Protein to Glycans Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Binding of the SARS-CoV-2 Spike Protein to Glycans
Creator	Cui, Sheng Hao, Wei Wang, Xiaoyu Qin, Bo Ma, Bo Gao, Xiaopan Li, Yaohao Li, Ziheng Shang, Shiying Tan, Zhongping
Source	BioRxiv
abstract	The pandemic of SARS-CoV-2 has caused a high number of deaths in the world. To combat it, it is necessary to develop a better understanding of how the virus infects host cells. Infection normally starts with the attachment of the virus to cell-surface glycans like heparan sulfate (HS) and sialic acid-containing oligosaccharides. In this study, we examined and compared the binding of the subunits and spike (S) proteins of SARS-CoV-2 and SARS-CoV, MERS-CoV to these glycans. Our results revealed that the S proteins and subunits can bind to HS in a sulfation-dependent manner, the length of HS is not a critical factor for the binding, and no binding with sialic acid residues was detected. Overall, this work suggests that HS binding may be a general mechanism for the attachment of these coronaviruses to host cells, and supports the potential importance of HS in infection and in the development of antiviral agents against these viruses.
has issue date	2020-07-02(xsd:dateTime)
bibo:doi	10.1101/2020.05.17.100537
has license	biorxiv
sha1sum (hex)	27df1fc2fa0fab2bd274ee77148eaadcb6b513db
schema:url	https://doi.org/10.1101/2020.05.17.100537
resource representing a document's title	Binding of the SARS-CoV-2 Spike Protein to Glycans
schema:publication	bioRxiv
resource representing a document's body	covid:27df1fc2fa0fab2bd274ee77148eaadcb6b513db#body_text
is schema:about of	named entity 'supports' named entity 'binding' named entity 'subunits' named entity 'CAUSED' named entity 'VIRUSES' named entity 'ANTIVIRAL AGENTS' named entity 'SURFACE' named entity 'CONTAINING' named entity 'SPIKE' named entity 'proteins' named entity 'Infection' named entity 'Overall' named entity 'virus' named entity 'proteins' named entity 'manner' named entity 'subunits' named entity 'virus' named entity 'glycans' named entity 'Binding' named entity 'Spike' named entity 'virus' named entity 'antiviral agents' named entity 'SARS-CoV' named entity 'glycans' named entity 'coronaviruses' named entity 'viruses' named entity 'heparan sulfate' named entity 'sulfation' named entity 'microarray study' named entity 'Hepes' named entity 'RBD' named entity 'micromolar' named entity 'monosaccharide' named entity 'molecule' named entity 'antiviral agents' named entity 'sulfation' named entity 'proteases' named entity 'sulfation' named entity 'SARS-CoV-2' named entity 'molecule' named entity 'acetylation' named entity 'microarray study' named entity 'protein' named entity 'dextran' named entity 'protein trimer' named entity 'SARS-CoV' named entity 'MERS-CoV' named entity 'SARS-CoV' named entity 'viruses' named entity 'receptor' named entity 'recombinant protein' named entity 'molecule' named entity 'CD26' named entity 'SARS-CoV-2' named entity 'RBD' named entity 'glucosamine' named entity 'nonstructural proteins' named entity 'SARS-CoV-2' named entity 'lungs' named entity 'protein' named entity 'sialic acid' named entity 'affinity column' named entity 'protein' named entity 'amino acid' named entity 'coronavirus' named entity 'sulfate' named entity 'oligosaccharides' named entity 'sulfate' named entity 'GAGs' named entity 'infection' named entity 'viruses' named entity 'protein' named entity 'SARS-CoV-2' named entity 'infection' named entity 'tropism'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software