About: Regulation of MAVS Expression and Signaling Function in the Antiviral Innate Immune Response

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About: Regulation of MAVS Expression and Signaling Function in the Antiviral Innate Immune Response Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulation of MAVS Expression and Signaling Function in the Antiviral Innate Immune Response
Creator	Wei, Zhanyong Xu, Zhiwen Lin, Shaoli Rehwinkel, Jan Zhu, Jianzhong Ding, Ting Ren, Zhihua Deng, Junliang Lopalco, Lucia Zuo, Zhicai
Source	Medline; PMC
abstract	Viral infection is controlled by host innate immune cells that express specialized receptors for viral components. Engagement of these pattern recognition receptors triggers a series of signaling pathways that culminate in the production of antiviral mediators such as type I interferons. Mitochondrial antiviral-signaling protein (MAVS) acts as a central hub for signal transduction initiated by RIG-I-like receptors, which predominantly recognize viral RNA. MAVS expression and function are regulated by both post-transcriptional and post-translational mechanisms, of which ubiquitination and phosphorylation play the most important roles in modulating MAVS function. Increasing evidence indicates that viruses can escape the host antiviral response by interfering at multiple points in the MAVS signaling pathways, thereby maintaining viral survival and replication. This review summarizes recent studies on the mechanisms by which MAVS expression and signaling are normally regulated and on the various strategies employed by viruses to antagonize MAVS activity, which may provide new insights into the design of novel antiviral agents.
has issue date	2020-05-27(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.01030
bibo:pmid	32536927
has license	cc-by
sha1sum (hex)	26aebf28d4267f9b70c373de991efc0b8d6988c6
schema:url	https://doi.org/10.3389/fimmu.2020.01030
resource representing a document's title	Regulation of MAVS Expression and Signaling Function in the Antiviral Innate Immune Response
has PubMed Central identifier	PMC7267026
has PubMed identifier	32536927
schema:publication	Front Immunol
resource representing a document's body	covid:26aebf28d4267f9b70c373de991efc0b8d6988c6#body_text
is schema:about of	named entity 'TRANSCRIPTIONAL' named entity 'TRANSLATIONAL' named entity 'protein' named entity 'MAVS' named entity 'Mfn2' named entity 'MAVS' named entity 'hepatitis viruses' named entity 'viral infection' named entity 'cysteine protease' named entity 'IFN' named entity 'RLR' named entity 'EV-D68' named entity 'kinases' named entity 'TBK1' named entity 'protein translation' named entity 'Mfn1' named entity 'MAVS' named entity 'signaling pathways' named entity 'viruses' named entity 'signaling pathways' named entity 'MAVS' named entity 'signaling protein' named entity 'viruses' named entity 'signal transduction' named entity 'Antiviral' named entity 'IRF3' named entity 'up-regulation' named entity 'MAVS' named entity 'antiviral' named entity 'hemagglutinating' named entity 'N-terminal' named entity 'caspase-3' named entity 'post-transcriptional' named entity 'MAVS' named entity 'kDa' named entity 'negative feedback mechanism' named entity 'staining' named entity 'amino acid' named entity 'Human cytomegalovirus' named entity 'AIM2' named entity 'viral infection' named entity 'Protein' named entity 'HCV' named entity 'Tetherin' named entity 'MAVS' named entity 'TRIM25' named entity 'TRAF6' named entity 'cyclophilin' named entity 'MAVS' named entity 'TRAF6' named entity 'SARS' named entity 'inducible gene' named entity 'Zika' named entity 'pattern recognition receptors' named entity 'mitochondria' named entity 'IRF3' named entity 'MAVS' named entity 'MAVS' named entity 'MAVS' named entity 'endoplasmic reticulum' named entity 'ovarian tumor' named entity 'upregulate' named entity 'isoforms' named entity 'apoptosis' named entity 'E3 ubiquitin ligase' named entity 'MAVS' named entity 'Mfn2' named entity 'MAVS' named entity 'mitochondrial' named entity 'NLRP11' named entity 'TRAF6' named entity 'metabolism'

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