About: Dataset for Homologous Proteins in Drosophila melanogaster for SARS-CoV-2/Human Interactome

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About: Dataset for Homologous Proteins in Drosophila melanogaster for SARS-CoV-2/Human Interactome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dataset for Homologous Proteins in Drosophila melanogaster for SARS-CoV-2/Human Interactome
Creator	Ashraf Baig, Ayesha Hussain, Mushtaq Amanullah, Anusha Baig, Ayesha Jabeen, Nusrat Shabbir, Sanya Aziz, Basma Raza, Fozia Udin, Nasir
Source	Elsevier; Medline; PMC
abstract	Animal modelling for infectious diseases is critical to understand the biology of the pathogens including viruses and to develop therapeutic strategies against it. Herein, we present the sequence homology and expression data analysis of proteins found in Drosophila melanogaster that are orthologous to human proteins, reported as components of SARS-CoV-2/Human interactome. The dataset enlists sequence homology, query coverage, domain conservation, OrthoMCL and Ensembl Genome Browser support of 326 proteins in D.melanogaster that are potentially orthologous to 417 human proteins reported for their direct physical interactions with 28 proteins encoded by SARS-CoV-2 genome. Expression of these D.melanogaster orthologous genes in 26 anatomical positions are also plotted as heat maps in 27 sets, corresponding to the potential protein interactors for each viral protein. The data could be used to direct experiments and potentially predict their phenotypic and molecular outcome in order to dissect the biological roles and molecular functionality of SARS-CoV-2 proteins in a convenient animal model system like D.melanogaster.
has issue date	2020-07-26(xsd:dateTime)
bibo:doi	10.1016/j.dib.2020.106082
bibo:pmid	32775582
has license	no-cc
sha1sum (hex)	26a314620b252a1807a484eeda589f025212f646
schema:url	https://doi.org/10.1016/j.dib.2020.106082
resource representing a document's title	Dataset for Homologous Proteins in Drosophila melanogaster for SARS-CoV-2/Human Interactome
has PubMed Central identifier	PMC7382932
has PubMed identifier	32775582
schema:publication	Data Brief
resource representing a document's body	covid:26a314620b252a1807a484eeda589f025212f646#body_text
is schema:about of	named entity 'proteins' named entity 'support' named entity 'therapeutic' named entity 'biology' named entity 'SARS-CoV-2' named entity 'GENOME' named entity 'HEAT' named entity 'HUMAN PROTEINS' named entity 'EXPERIMENTS' named entity 'UNDERSTAND' named entity 'PATHOGENS' named entity 'viral protein' named entity 'system' named entity 'proteins' named entity 'sets' named entity 'proteins' named entity 'SARS-CoV-2' named entity 'proteins' named entity 'potential' named entity 'plotted' named entity 'phenotypic' named entity 'interactions' named entity 'Proteins' named entity 'Human interactome' named entity 'phenotypic' named entity 'viral protein' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'Drosophila melanogaster' named entity 'data analysis' named entity 'NCBI Blast' named entity 'D.melanogaster' named entity 'SARS-CoV-2' named entity 'orthologues' named entity 'COVID-19' named entity 'Ensembl' named entity 'protein interactions' named entity 'Interactome' named entity 'SARS-CoV-2' named entity 'genome' named entity 'fruit fly' named entity 'Genetics' named entity 'cloning' named entity 'anatomical' named entity 'CPU' named entity 'sequence identity' named entity 'BLAST search' named entity 'Interactome' named entity 'genome' named entity 'Orthologues' named entity 'gene' named entity 'SARS-CoV-2' named entity '1, 2' named entity 'repurposing drugs' named entity 'sequence identity' named entity 'mRNA' named entity 'orthologues' named entity 'D.melanogaster' named entity 'SARS-CoV-2' named entity 'viral infection' named entity 'orthologues' named entity 'D.melanogaster' named entity 'D.melanogaster' named entity 'orthologue' named entity 'D.melanogaster' named entity 'anatomical' named entity 'bioinformatic analysis' named entity 'drug target' named entity 'Orthologues' named entity 'Cytoscape' named entity 'pharmacologists' named entity 'Cytoscape' named entity 'Ensembl Genome Browser'

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