About: Evaluation of the genetic variability found in Brazilian commercial vaccines for infectious bronchitis virus

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About: Evaluation of the genetic variability found in Brazilian commercial vaccines for infectious bronchitis virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of the genetic variability found in Brazilian commercial vaccines for infectious bronchitis virus
Creator	Bressan, Gustavo Silva-Júnior, Abelardo Claiton, · De Almeida, Rogéria De, Antonio Fietto, Rangel Jamária, · Lopes, Juliana Loreto Saraiva, Giuliana Marcus, Pedro Marcus, · Mendes, Oliveira Márcia, · Pereira, Gonçalves Santos, Rebouças Soares-Martins, A Tiago, · Vidigal, Pereira
Source	Medline; PMC
abstract	Infectious bronchitis virus (IBV) is currently one of the most important pathogens in the poultry industry. The H120 and Ma5 are the only viral strains approved by the Brazilian government as the constituent of vaccines. Despite the systematic vaccination in Brazil, IBV has not yet been controlled and diseases associated with this virus have been reported in vaccinated chickens. Here, we investigated the genetic variability of H120 and Ma5 strains present in the IBV vaccines from different Brazilian manufacturers. We performed DNA sequencing analyses of the S1 spike glycoprotein gene to investigate its genetic variability and the presence of viral subpopulations among vaccines, between batches, and also in each vaccine after a single passage was performed in chicken embryonated eggs. Our results revealed up to 13 amino acid substitutions among vaccines and some of them were localized in regions of the S1 glycoprotein that play a role in virus–host interaction. Secondary nucleotide peaks identified in the chromatogram for the S1 gene sequence revealed that all original vaccines (H120 and Ma5) were composed by different subpopulations of IBV. Moreover, new viral subpopulations were also found in vaccines after a single passage in chicken embryonated eggs. These findings indicate that H120 and Ma5 viral strains used in vaccines market in Brazil can still mutate very rapidly during replication, leading to amino acid substitutions in proteins involved in the stimulation of the immune response, such as the S1 glycoprotein. Therefore, our data suggest that the genetic variability of these viral strains should be taken into consideration to ensure an effective immune response against IBV. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11262-017-1515-2) contains supplementary material, which is available to authorized users.
has issue date	2017-11-11(xsd:dateTime)
bibo:doi	10.1007/s11262-017-1515-2
bibo:pmid	29128885
has license	no-cc
sha1sum (hex)	26456447f82d0213de7a9cb40db7eb5cdda8d507
schema:url	https://doi.org/10.1007/s11262-017-1515-2
resource representing a document's title	Evaluation of the genetic variability found in Brazilian commercial vaccines for infectious bronchitis virus
has PubMed Central identifier	PMC7089498
has PubMed identifier	29128885
schema:publication	Virus Genes
resource representing a document's body	covid:26456447f82d0213de7a9cb40db7eb5cdda8d507#body_text
is schema:about of	named entity 'FOUND' named entity 'vaccines' named entity 'sequence' named entity 'strains' named entity 'regions' named entity 'vaccines' named entity 'REGIONS' named entity 'ROLE' named entity 'S1 GENE' named entity 'LEADING' named entity 'DIFFERENT' named entity 'GLYCOPROTEIN' named entity 'REVEALED' named entity 'AMINO ACID SUBSTITUTIONS' named entity 'EFFECTIVE' named entity 'COMMERCIAL' named entity 'EVALUATION' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'BRAZILIAN' named entity 'GENETIC VARIABILITY' named entity 'PEAKS' named entity 'REPLICATION' named entity 'VACCINES' named entity 'THESE' named entity 'SUGGEST' named entity 'VACCINES' named entity 'SECONDARY' named entity 'IMMUNE RESPONSE' named entity 'PROTEINS' named entity 'CHICKEN' named entity 'MA5' named entity 'TAKEN' named entity 'GENETIC VARIABILITY' named entity 'MARKET' named entity 'STRAINS' named entity 'DATA' named entity 'FINDINGS' named entity 'USED' named entity 'LOCALIZED' named entity 'IBV' named entity 'INVOLVED' named entity 'NEW' named entity 'ORIGINAL' named entity 'PASSAGE' named entity 'ENSURE' named entity 'FOUND' named entity 'STIMULATION' named entity 'EGGS' named entity 'CONSIDERATION' named entity 'UP TO' named entity 'VIRUS-HOST INTERACTION' named entity 'RAPIDLY' named entity 'PLAY' named entity 'OUR' named entity 'SINGLE' named entity 'VIRAL' named entity 'NUCLEOTIDE' named entity 'IDENTIFIED' named entity 'MUTATE' named entity 'CHROMATOGRAM' named entity 'BRAZIL' covid:arg/26456447f82d0213de7a9cb40db7eb5cdda8d507 named entity 'IBV' named entity 'ensure'

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