About: Distribution and seasonality of rhinovirus and other respiratory viruses in a cross-section of asthmatic children in Trinidad, West Indies

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About: Distribution and seasonality of rhinovirus and other respiratory viruses in a cross-section of asthmatic children in Trinidad, West Indies Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Distribution and seasonality of rhinovirus and other respiratory viruses in a cross-section of asthmatic children in Trinidad, West Indies
Creator	Lee, Wai-Ming Matthew, Jason Grindle, Kris Pappas, Tressa Gern, James Lemanske, Robert Roberg, Kathy Lexley, Pereira, Pinto Swenson, Cheri
Source	Medline; PMC
abstract	BACKGROUND: Childhood asthma in the Caribbean is advancing in prevalence and morbidity. Though viral respiratory tract infections are reported triggers for exacerbations, information on these infections with asthma is sparse in Caribbean territories. We examined the distribution of respiratory viruses and their association with seasons in acute and stable asthmatic children in Trinidad. METHODS: In a cross-sectional study of 70 wheezing children attending the emergency department for nebulisation and 80 stable control subjects (2 to 16 yr of age) in the asthma clinic, nasal specimens were collected during the dry (n = 38, January to May) and rainy (n = 112, June to December) seasons. A multitarget, sensitive, specific high-throughput Respiratory MultiCode assay tested for respiratory-virus sequences for eight distinct groups: human rhinovirus, respiratory syncytial virus, parainfluenza virus, influenza virus, metapneumovirus, adenovirus, coronavirus, and enterovirus. RESULTS: Wheezing children had a higher [χ(2 )= 5.561, p = 0.018] prevalence of respiratory viruses compared with stabilized asthmatics (34.3% (24) versus (vs.) 17.5% (14)). Acute asthmatics were thrice as likely to be infected with a respiratory virus (OR = 2.5, 95% CI = 1.2 – 5.3). The predominant pathogens detected in acute versus stable asthmatics were the rhinovirus (RV) (n = 18, 25.7% vs. n = 7, 8.8%; p = 0.005), respiratory syncytial virus B (RSV B) (n = 2, 2.9% vs. n = 4, 5.0%), and enterovirus (n = 1, 1.4% vs. n = 2, 2.5%). Strong odds for rhinoviral infection were observed among nebulised children compared with stable asthmatics (p = 0.005, OR = 3.6, 95% CI = 1.4 – 9.3,). RV was prevalent throughout the year (Dry, n = 6, 15.8%; Rainy, n = 19, 17.0%) and without seasonal association [χ(2 )= 0.028, p = 0.867]. However it was the most frequently detected virus [Dry = 6/10, (60.0%); Rainy = 19/28, (67.9%)] in both seasons. CONCLUSION: Emergent wheezing illnesses during childhood can be linked to infection with rhinovirus in Trinidad's tropical environment. Viral-induced exacerbations of asthma are independent of seasons in this tropical climate. Further clinical and virology investigations are recommended on the role of infections with the rhinovirus in Caribbean childhood wheeze.
has issue date	2009-06-25(xsd:dateTime)
bibo:doi	10.1186/1824-7288-35-16
bibo:pmid	19555507
has license	cc-by
sha1sum (hex)	25f4a5990fcb174f80bc472629eb47be50d5b3f7
schema:url	https://doi.org/10.1186/1824-7288-35-16
resource representing a document's title	Distribution and seasonality of rhinovirus and other respiratory viruses in a cross-section of asthmatic children in Trinidad, West Indies
has PubMed Central identifier	PMC2717562
has PubMed identifier	19555507
schema:publication	Ital J Pediatr
resource representing a document's body	covid:25f4a5990fcb174f80bc472629eb47be50d5b3f7#body_text
is schema:about of	named entity 'RHINOVIRUS' named entity 'acute' named entity 'DISTRIBUTION' named entity 'ITALIAN' named entity 'PEDIATRICS' covid:arg/25f4a5990fcb174f80bc472629eb47be50d5b3f7 named entity 'TRINIDAD' named entity 'DISTRIBUTION' named entity 'EXAMINED' named entity 'JOURNAL ' named entity 'WEST INDIES' named entity 'TRINIDAD' named entity 'ASTHMATIC' named entity 'ASTHMATIC' named entity 'INFORMATION' named entity 'INFECTIONS' named entity 'STABLE' named entity 'VIRAL' named entity 'CHILDREN' named entity 'SEASONALITY' named entity 'RESPIRATORY VIRUSES' named entity 'THEIR' named entity 'SPARSE' named entity 'ADVANCING' named entity 'ASTHMA' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'TRIGGERS' named entity 'THESE' named entity 'CARIBBEAN' named entity 'SEASONS' named entity 'BACKGROUND' named entity 'REPORTED' named entity 'RESPIRATORY VIRUSES' named entity 'MORBIDITY' named entity 'CHILDHOOD ASTHMA' named entity 'ASSOCIATION' named entity 'PREVALENCE' named entity 'CROSS-SECTION' named entity 'ACUTE' named entity 'CHILDREN' named entity 'asthma' named entity 'asthmatic' named entity 'viruses' named entity 'asthmatic' named entity 'Caribbean' named entity 'Trinidad' named entity 'rhinovirus' named entity 'Canada' named entity 'rhinovirus' named entity 'asthma' named entity 'asthma' named entity 'thrice' named entity 'viruses' named entity 'rhinovirus' named entity 'viruses' named entity 'asthmatic' named entity 'asthma' named entity 'viral infection' named entity 'patient recruitment' named entity 'asthmatics' named entity 'seasonality' named entity 'nebulised' named entity 'asthma' named entity 'asthma' named entity 'RSV' named entity 'retrospective study' named entity 'RSV infection' named entity 'RSV infection' named entity 'common cold viruses' named entity 'rainy seasons' named entity 'rainy season' named entity 'asthma exacerbations'

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