About: A new and rapid approach for detecting COVID‐19 based on S1 protein fragments

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About: A new and rapid approach for detecting COVID‐19 based on S1 protein fragments Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A new and rapid approach for detecting COVID‐19 based on S1 protein fragments
Creator	Zhang, Yong Ma, Yuanyuan Chen, Jie Li, Hua Liu, Zhe Ge, Junbo Wang, Xiangdong Qi, Yingjie He, Yue Jiang, Liu Lai, Kaisheng Liu, Fujia
Source	Medline; PMC
abstract	The pandemic of novel coronavirus disease 2019 (COVID‐19) seriously threatened the public health all over the world. A colloidal gold immunochromatography assay for IgM/IgG antibodies against the receptor‐binding domain of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) S1 protein was established to assess its rapid diagnostic value. We first designed and manufactured all contents of the test cassette of SARS‐CoV‐2 rapid test kit: the colloidal gold‐labeled mouse‐antihuman lgM/lgG antibody, the recombinant SARS‐CoV‐2 antigen, the nitrocellulose membrane control line, and specimen diluents. Furthermore, reverse transcription‐polymerase chain reaction (RT‐PCR) assay, colloidal gold immunochromatography assay, serological validation of cross reaction with other common viruses, and clinical validation were performed. The kit was finally evaluated by 75 serum/plasma samples of SARS‐CoV‐2 infection cases and 139 healthy samples as control, with the result of that the sensitivity, specificity, and accuracy for IgM were 90.67%, 97.84%, and 95.33%, whereas for IgG were 69.33%, 99.28%, and 88.79%, respectively; the combination of IgM and IgG could improve the value: 92.00%, 97.12%, and 95.33%, respectively. Therefore, the rapid detection kit has high sensitivity and specificity, especially for IgM&IgG, showing a critical value in clinical application and epidemic control of COVID‐19.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1002/ctm2.90
bibo:pmid	32508026
has license	cc-by
sha1sum (hex)	25a534a6c6de03af0f962f647ab2d6d436276c8f
schema:url	https://doi.org/10.1002/ctm2.90
resource representing a document's title	A new and rapid approach for detecting COVID‐19 based on S1 protein fragments
has PubMed Central identifier	PMC7427819
has PubMed identifier	32508026
schema:publication	Clin Transl Med
resource representing a document's body	covid:25a534a6c6de03af0f962f647ab2d6d436276c8f#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity 'IgG' named entity 'nitrocellulose' named entity 'protein' named entity 'PCR' named entity 'COMBINATION' named entity 'COVID-19' named entity 'ITS' named entity 'HEALTHY' named entity 'DETECTION' named entity 'COLLOIDAL' named entity 'IMMUNOCHROMATOGRAPHY ASSAY' named entity 'TEST' named entity 'SPECIFICITY' named entity 'SEROLOGICAL' named entity 'RECOMBINANT' named entity 'CROSS REACTION' named entity 'ACCURACY' named entity 'sensitivity' named entity 'rapid' named entity 'IgG' named entity 'critical' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'assay' named entity 'antigen' named entity 'SARS-CoV-2' named entity 'assay' named entity 'IgG' named entity 'SARS-CoV-2' named entity 'antibody' named entity 'nucleic acid detection' named entity 'nucleic acid test' named entity 'SARS-CoV-2' named entity 'viral infection' named entity 'Colloidal gold' named entity 'antibody' named entity 'nucleic acid test' named entity 'IgG antibody' named entity 'ethylenediaminetetraacetic acid' named entity 'COVID-19' named entity 'serological' named entity 'antigen' named entity 'rapid test' named entity 'viral infection' named entity 'IgM' named entity 'early diagnosis' named entity 'assay' named entity 'immune response' named entity 'recombinant' named entity 'recombinant' named entity 'homology' named entity 'antibody' named entity 'IgG antibody' named entity 'diluent' named entity 'SARS-CoV-2' named entity 'nucleic acid detection' named entity 'COVID' named entity 'antigen' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'antibody' named entity 'IgG' named entity 'assay' named entity 'recombinant' named entity 'IgM' named entity 'antibodies' named entity 'antibody' named entity 'IgG' named entity 'Reverse Transcription' named entity 'coronavirus'

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