About: Characterization of Influenza A Virus Infection in Mouse Pulmonary Stem/Progenitor Cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of Influenza A Virus Infection in Mouse Pulmonary Stem/Progenitor Cells
Creator	Auewarakul, Prasert Chang, Sui-Yuan Chao, Tai-Ling Chou, Yu-Tien Gu, Sing-Yi Lin, Pi-Han Ling, Thai-Yen Iwatsuki-Horimoto, Kiyoko Abdelwhab, El-Sayed Chao, T-L Chou, P-H Lin, Gu S-Y
Source	PMC
abstract	The pulmonary stem/progenitor cells, which could be differentiated into downstream cells to repair tissue damage caused by influenza A virus, have also been shown to be the target cells of influenza virus infection. In this study, mouse pulmonary stem/progenitor cells (mPSCs) with capability to differentiate into type I or type II alveolar cells were used as an in vitro cell model to characterize replication and pathogenic effects of influenza viruses in PSCs. First, mPSCs and its immortalized cell line mPSCs(Oct4+) were shown to be susceptible to PR8, seasonal H1N1, 2009 pandemic H1N1, and H7N9 influenza viruses and can generate infectious virus particles, although with a lower virus titer, which could be attributed by the reduced vRNA replication and nucleoprotein (NP) aggregation in the cytoplasm. Nevertheless, a significant increase of interleukin (IL)-6 and interferon (IFN)-γ at 12 h and IFN-β at 24 h post infection in mPSCs implicates that mPSCs might function as a sensor to modulate immune responses to influenza virus infection. In summary, our results demonstrated mPSCs, as one of the target cells for influenza A viruses, could modulate early proinflammatory responses to influenza virus infection.
has issue date	2020-01-21(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.02942
bibo:pmid	32038512
has license	cc-by
sha1sum (hex)	2522231ac6a1faeccfaf8f71e1bdc7cc81c7c647
schema:url	https://doi.org/10.3389/fmicb.2019.02942
resource representing a document's title	Characterization of Influenza A Virus Infection in Mouse Pulmonary Stem/Progenitor Cells
has PubMed Central identifier	PMC6985155
has PubMed identifier	32038512
schema:publication	Front Microbiol
resource representing a document's body	covid:2522231ac6a1faeccfaf8f71e1bdc7cc81c7c647#body_text
is schema:about of	named entity 'Pulmonary' named entity 'STEM' named entity 'PULMONARY' named entity 'CHARACTERIZATION' named entity 'INFLUENZA A VIRUS INFECTION' named entity 'CELLS' named entity 'MOUSE' named entity 'Influenza A Virus' named entity 'Infection' named entity 'interferon' named entity 'ethanol' named entity 'virus replication' named entity 'alveoli' named entity 'PVDF' named entity 'E3L' named entity 'Invitrogen' named entity 'influenza virus' named entity 'Streptavidin' named entity 'cytokines' named entity 'sialic acid' named entity 'MDCK' named entity 'United States' named entity 'hpi' named entity 'transmission electron microscope' named entity 'United States' named entity 'mRNA' named entity 'cell lines' named entity 'cytokine' named entity 'flow cytometry' named entity 'vRNP' named entity 'influenza' named entity 'virus infection' named entity 'vRNA' named entity 'hpi' named entity 'supernatant' named entity 'stem/progenitor cells' named entity 'PBS' named entity 'influenza virus' named entity 'virus' named entity 'black arrow' named entity 'MDCK' named entity 'MDCK' named entity 'virus replication' named entity 'virus' named entity 'TEM' named entity 'TNFα' named entity 'uranyl acetate' named entity 'retroviruses' named entity 'H1N1' named entity 'viruses' named entity 'United States' named entity 'RNA' named entity 'virus' named entity 'virus' named entity 'infection' named entity 'supernatants' named entity 'virus' named entity 'lysed' named entity 'IFN' named entity 'RNA' named entity 'significant difference' named entity 'mRNA' named entity 'viruses' named entity 'RNA' named entity 'MDCK' named entity 'IL-9' named entity 'infection' named entity 'virus' named entity 'sialic acid' named entity 'vascular endothelial growth factor'

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