About: B-cell activation in cats with feline infectious peritonitis (FIP) by FIP-virus-induced B-cell differentiation/survival factors

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About: B-cell activation in cats with feline infectious peritonitis (FIP) by FIP-virus-induced B-cell differentiation/survival factors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	B-cell activation in cats with feline infectious peritonitis (FIP) by FIP-virus-induced B-cell differentiation/survival factors
Creator	Hohdatsu, Tsutomu Takano, Tomomi Hashida, Yoshikiyo Ae, Azuma Ae, Satoh Natsuko, A Ryoichi, A
Source	Medline; PMC
abstract	It has been suggested that antibody overproduction plays a role in the pathogenesis of feline infectious peritonitis (FIP). However, only a few studies on the B-cell activation mechanism after FIP virus (FIPV) infection have been reported. The present study shows that: (1) the ratio of peripheral blood sIg(+) CD21(−) B-cells was higher in cats with FIP than in SPF cats, (2) the albumin-to-globulin ratio has negative correlation with the ratio of peripheral blood sIg(+) CD21(−) B-cell, (3) cells strongly expressing mRNA of the plasma cell master gene, B-lymphocyte-induced maturation protein 1 (Blimp-1), were increased in peripheral blood in cats with FIP, (4) mRNA expression of B-cell differentiation/survival factors, IL-6, CD40 ligand, and B-cell-activating factor belonging to the tumor necrosis factor family (BAFF), was enhanced in macrophages in cats with FIP, and (5) mRNAs of these B-cell differentiation/survival factors were overexpressed in antibody-dependent enhancement (ADE)-induced macrophages. These data suggest that virus-infected macrophages overproduce B-cell differentiation/survival factors, and these factors act on B-cells and promote B-cell differentiation into plasma cells in FIPV-infected cats.
has issue date	2008-11-30(xsd:dateTime)
bibo:doi	10.1007/s00705-008-0265-9
bibo:pmid	19043660
has license	no-cc
sha1sum (hex)	251dd2827ce520fe189947ea22457211ed8224c6
schema:url	https://doi.org/10.1007/s00705-008-0265-9
resource representing a document's title	B-cell activation in cats with feline infectious peritonitis (FIP) by FIP-virus-induced B-cell differentiation/survival factors
has PubMed Central identifier	PMC7087278
has PubMed identifier	19043660
schema:publication	Arch Virol
resource representing a document's body	covid:251dd2827ce520fe189947ea22457211ed8224c6#body_text
is schema:about of	named entity 'FIP' named entity 'CATS' named entity 'GENE' named entity 'SPF' named entity 'REPORTED' named entity 'MACROPHAGES' named entity 'RATIO' named entity 'STUDIES' named entity 'INFECTED' named entity 'CD40 LIGAND' named entity 'B-LYMPHOCYTE-INDUCED MATURATION PROTEIN 1' named entity 'INCREASED' named entity 'MRNA EXPRESSION' named entity 'SUGGEST' named entity 'IL-6' named entity 'PLAYS' named entity 'THESE' named entity 'PLASMA CELL' named entity 'ROLE' named entity 'INDUCED' named entity 'CELLS' named entity 'SIG' named entity 'MASTER' named entity 'FIPV' named entity '282' named entity 'PROMOTE' named entity 'INDUCED' named entity 'CD21' named entity 'GLOBULIN' named entity 'STUDY' named entity 'B-CELLS' named entity 'VIRUS' named entity 'CORRELATION' named entity 'FAMILY' named entity 'CATS' named entity 'FIP' named entity 'PLASMA CELLS' named entity 'ACT' named entity 'NEGATIVE' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'VIRUS' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'B-CELL ACTIVATION' named entity 'B-CELL DIFFERENTIATION' named entity 'HAVE' named entity 'B-CELL-ACTIVATING FACTOR' named entity 'B-CELL' named entity 'DATA' named entity 'ANTIBODY' named entity 'B-CELL DIFFERENTIATION' named entity '283' named entity 'B-CELL ACTIVATION' named entity 'TUMOR NECROSIS FACTOR ' named entity 'PRESENT' named entity 'PATHOGENESIS' named entity 'HIGHER' named entity 'MRNA' named entity 'INFECTION' named entity 'ENHANCEMENT' named entity 'ACTIVATION MECHANISM' named entity 'ALBUMIN' named entity 'BELONGING' named entity 'PERIPHERAL BLOOD' named entity 'ENHANCED' covid:arg/251dd2827ce520fe189947ea22457211ed8224c6 named entity 'mRNA' named entity 'FIP' named entity 'macrophages' named entity 'IL-6' named entity 'antibody' named entity 'virus' named entity 'protein' named entity 'CD40 ligand' named entity 'gene' named entity 'feline infectious peritonitis'

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