About: Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette I. Inhalation toxicology and histopathology

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About: Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette I. Inhalation toxicology and histopathology Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette I. Inhalation toxicology and histopathology
Creator	Sagartz, John Ayres, Paul Coggins, Christopher Coggins, Histopathology Hayes, A Mosberg, Arnold Ogden, A Ogden, Michael Reynolds, R Sagartz, M
source	Elsevier; Medline; PMC
abstract	Abstract Sprague-Dawley rats were exposed 6 hr per day for 14 consecutive days to aged and diluted sidestream smoke (ADSS), used as a surrogate for Environmental Tobacco Smoke (ETS), at concentrations of 0.1 (typical), 1 (extreme), or 10 (exaggerated) mg of particulates per cubic meter. Animals were exposed nose-only, inside whole-body chambers, to ADSS from the 1R4F reference cigarette. End-points included histopathology, CO-oximetry, plasma nicotine and cotinine, clinical pathology, and organ and body weights. The only pathological response observed was slight to mild epithelial hyperplasia and inflammation in the most rostral part of the nasal cavity, in the high-exposure group only. No effects were noted at medium or low exposures. The minimal changes noted were reversible, using a subgroup of animals kept without further treatment for an additional 14 days. Overall, the end-points used in the study demonstrated that there was no detectable biological activity of ADSS at typical or even 10-fold ETS concentrations and that the activity was only minimal at very exaggerated concentrations (particle concentrations 100 times higher than typical real-world concentrations).
has issue date	1992-07-31(xsd:dateTime)
bibo:doi	10.1016/0272-0590(92)90037-i
bibo:pmid	1397794
has license	els-covid
sha1sum (hex)	2503fd9af0e8e85e9cd3c3eb56465951120b252a
schema:url	https://doi.org/10.1016/0272-0590%2892%2990037-i
resource representing a document's title	Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette I. Inhalation toxicology and histopathology
has PubMed Central identifier	PMC7130663
has PubMed identifier	1397794
schema:publication	Fundamental and Applied Toxicology
resource representing a document's body	covid:2503fd9af0e8e85e9cd3c3eb56465951120b252a#body_text
is schema:about of	named entity 'Smoke' named entity 'Study' named entity 'Inhalation' named entity 'HISTOPATHOLOGY' named entity 'AGED' named entity 'TOXICOLOGY' named entity 'RATS' named entity 'DILUTED' named entity 'INHA' named entity 'INHALATION TOXICOLOGY' named entity 'SMOKE' named entity 'FOURTEEN' named entity 'DAY' named entity 'REFERENCE CIGARETTE' named entity 'USING' named entity 'STUDY' named entity 'INHALATION' named entity 'Reference' named entity 'luted' named entity 'Toxicology' named entity 'Inhalation' named entity 'Sidestream Smoke' named entity 'Inhalation' named entity 'DNA adducts' named entity 'epithelial' named entity 'WTPM' named entity 'lungs' named entity 'alanine aminotransferase' named entity 'body weight' named entity '13.5' named entity 'sternum' named entity 'vena cava' named entity 'cranium' named entity 'adsorption' named entity 'Necropsy' named entity 'aerosol' named entity 'nicotine' named entity 'Westwood, NJ' named entity 'necropsy' named entity 'nasal cavity' named entity 'WTPM' named entity 'suspended particulates' named entity 'lesion' named entity 'albumin' named entity 'polymorphonuclear leukocytes' named entity 'red blood cell' named entity 'combustion' named entity 'treatment groups' named entity 'histopathology' named entity 'Piscataway' named entity 'ADSS' named entity 'anesthetizing' named entity 'necropsy' named entity 'hemolysis' named entity 'hyperplasia' named entity 'pathologist' named entity 'WTPM' named entity 'duodenum' named entity 'saline' named entity 'Mycoplasma pulmonis' named entity 'hemoglobin' named entity 'incisor teeth' named entity 'ppm' named entity 'Solanesol' named entity 'Tissues' named entity 'aerosol' named entity 'inflammation' named entity 'Albuquerque' named entity 'esophagus' named entity 'Sidestream smoke' named entity 'femur' named entity 'Antibody testing'

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