About: Epidemiological and clinical features of COVID-19 patients with and without pneumonia in Beijing, China

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About: Epidemiological and clinical features of COVID-19 patients with and without pneumonia in Beijing, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epidemiological and clinical features of COVID-19 patients with and without pneumonia in Beijing, China
Creator	Shi, Lei Chen, Zhu Li, Ping Zhao, Peng Yang, Penghui Zhang, Shaogeng Zhao, Min Yu, Peng Cao, Guangwen Ding, Yibo Yang, P Li, P Chen, C Xu, Zhe Huang, Lei Wang, F-S Zhang, Dawei Cao, G-W Ding, Y Hong, Zhixian Huang, L Ji, Junsheng Jiang, T Jiang, Tianjun Liu, J Liu, Jiluo Meng, F Meng, Fanping Phd, Hong Phd, Pu Phd, Wang Phd, Yu Phd, Zhu Pu, Rui Qin, E Qin, Enqiang Shi, L Wang, Fusheng Wang, Zhaohai Xi, Qing Xiao, Z Xiao, Zhaohui Xu, Z Yan Bsc, J Yan, Jin Yu, Lingxiang Zhang, D Zhao, D Zhao, Dexi Zhao, M Zhu, Caizhong
Source	MedRxiv
abstract	Background:SARS-CoV-2-caused coronavirus disease (COVID-19) is posinga large casualty. The features of COVID-19patients withand without pneumonia,SARS-CoV-2 transmissibility in asymptomatic carriers, and factors predicting disease progression remain unknown. Methods: We collected information on clinical characteristics, exposure history, andlaboratory examinations of all laboratory-confirmed COVID-19 patients admitted to PLA General Hospital. Cox regression analysis was applied to identify prognostic factors. The last follow-up was February 18, 2020. Results:We characterized 55 consecutive COVID-19 patients. The mean incubation was 8.42(95% confidence interval [CI], 6.55-10.29) days. The mean SARS-CoV-2-positive duration from first positive test to clearance was 9.71(95%CI, 8.21-11.22) days. COVID-19 course was approximately 2 weeks. Asymptomatic carriers might transmit SARS-CoV-2. Compared with patients without pneumonia, those with pneumonia were 15 years older and had a higher rate of hypertension, higher frequencies of having a fever and cough, and higher levels of interleukin-6 (14.61 vs. 8.06pg/mL, P=0.040), B lymphocyte proportion (13.0% vs.10.0%, P=0.024), low account (<190/μL) of CD8+ T cells (33.3% vs. 0, P=0.019). Multivariate Cox regression analysis indicated that circulating interleukin-6 andlactate independently predicted COVID-19 progression, with a hazard ratio (95%CI) of 1.052 (1.000-1.107) and 1.082 (1.013-1.155), respectively. During disease course,T lymphocytes were generally lower,neutrophils higher, in pneumonia patients than in pneumonia-free patients. CD8+ lymphocytes did not increase at the 20th days after illness onset. Conclusion: The epidemiological features areimportant for COVID-19 prophylaxis. Circulating interleukin-6 and lactateare independent prognostic factors. CD8+ T cell exhaustion might be critical in the development of COVID-19.
has issue date	2020-03-03(xsd:dateTime)
bibo:doi	10.1101/2020.02.28.20028068
has license	medrxiv
sha1sum (hex)	24e17488d399c436305c819953beae2961214771
schema:url	https://doi.org/10.1101/2020.02.28.20028068
resource representing a document's title	Epidemiological and clinical features of COVID-19 patients with and without pneumonia in Beijing, China
resource representing a document's body	covid:24e17488d399c436305c819953beae2961214771#body_text
is schema:about of	named entity 'PATIENTS' named entity 'account' named entity 'HYPERTENSION' named entity 'RESULTS' covid:arg/24e17488d399c436305c819953beae2961214771 named entity 'PNEUMONIA' named entity '052' named entity 'COX REGRESSION' named entity 'PREDICTED' named entity 'SARS-COV-2' named entity 'CIRCULATING' named entity 'TO IDENTIFY' named entity 'CLINICAL FEATURES' named entity 'EPIDEMIOLOGICAL' named entity 'INDICATED' named entity 'APPLIED' named entity 'REGRESSION ANALYSIS' named entity 'YEARS' named entity 'METHODS' named entity 'B LYMPHOCYTE' named entity '040' named entity 'PREDICTING' named entity 'UNKNOWN' named entity 'ADMITTED TO' named entity 'EXAMINATIONS' named entity 'CHINA' named entity 'COURSE' named entity 'EXPOSURE HISTORY' named entity '2 WEEKS' named entity 'RATE' named entity 'LARGE' named entity 'CONFIRMED' named entity 'LEVELS' named entity 'POSING' named entity 'FEATURES'

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