About: Viral etiologies of acute respiratory tract infections among hospitalized children – A comparison between single and multiple viral infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral etiologies of acute respiratory tract infections among hospitalized children – A comparison between single and multiple viral infections
Creator	Chan, Yu-Jiun Chang, Chia-Yuan Hung, Miao-Chiu Lai, Chou-Cheng Wong, Ying-Chi Wu, Keh-Gong Wu, Wan-Tai Yen, Chun-Yu
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Acute respiratory tract infections are commonly caused by viruses in children. The differences in clinical data and outcome between single and multiple viral infections in hospitalized children were analyzed. METHODS: We retrospectively reviewed the medical records of hospitalized children who had fever and a xTAG Respiratory Virus Panel (RVP) test over a 2-year period. The clinical data were analyzed and compared between single and multiple viral infections. Viral etiologies in upper and lower respiratory infections were analyzed and compared. RESULTS: A total of 442 patients were enrolled. Patients with positive viral detection (N = 311) had a significantly lower rate of leukocytosis (p = 0.03), less evidence of bacterial infection (p = 0.004), and shorter duration of hospitalization (p = 0.019) than those with negative viral detection. The age of patients with multiple viral infections was younger than those with single viral infection; however, there were no significant differences in duration of fever, antibiotics treatment and hospitalization between these two groups. The most commonly identified virus was human rhinovirus. About 27% (n = 83) of patients had multiple viral infections. Overall, the highest percentage of human bocavirus infection was detected in multiple viral infections (79%). Lower respiratory tract infection (LRTI) was independently associated with multiple viral infections (p = 0.022), respiratory syncytial virus (RSV) infection (p = 0.001) and longer hospitalization duration (p = 0.011). CONCLUSION: Multiple viral infections were associated with younger age and a higher risk of developing LRTI. However, multiple viral infections did not predict a worse disease outcome. More studies are needed to unveil the interplay between the hosts and different viruses in multiple viral infections.
has issue date	2019-09-30(xsd:dateTime)
bibo:doi	10.1016/j.jmii.2019.08.013
bibo:pmid	31607575
has license	no-cc
sha1sum (hex)	2480b2d6683049fbd9522d1b2e8dd1ea006fb122
schema:url	https://doi.org/10.1016/j.jmii.2019.08.013
resource representing a document's title	Viral etiologies of acute respiratory tract infections among hospitalized children – A comparison between single and multiple viral infections
has PubMed Central identifier	PMC7105047
has PubMed identifier	31607575
schema:publication	J Microbiol Immunol Infect
resource representing a document's body	covid:2480b2d6683049fbd9522d1b2e8dd1ea006fb122#body_text
is schema:about of	named entity 'ETIOLOGIES' named entity 'Patients' named entity '311' named entity 'antibiotics' named entity 'viral' named entity 'Viral' named entity 'VIRAL' named entity 'ANTIBIOTICS' named entity 'VIRAL INFECTIONS' named entity 'TREATMENT' named entity '311' named entity 'POSITIVE' named entity 'TEST' named entity 'NEGATIVE' named entity 'AGE' named entity 'COMPARISON' named entity 'VIRUSES' named entity 'GROUPS' named entity '004' named entity 'SINGLE' named entity 'THESE' named entity 'METHODS' named entity 'FEVER' named entity 'MULTIPLE' named entity 'RATE' named entity 'YEAR' named entity 'MEDICAL RECORDS' named entity '442' named entity 'DURATION' named entity 'LEUKOCYTOSIS' named entity 'HOSPITALIZED CHILDREN' named entity 'PATIENTS' named entity 'OUTCOME' named entity '0.03' named entity 'BACKGROUND' named entity 'YOUNGER' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'VIRAL INFECTIONS' named entity 'REVIEWED' named entity 'LOWER' named entity 'SIGNIFICANT' named entity 'ANALYZED' named entity '28P' named entity 'RESPIRATORY VIRUS' named entity 'HOSPITALIZATION' named entity 'RESPIRATORY INFECTIONS' named entity 'SINGLE' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'ACUTE' named entity 'CHILDREN' named entity 'ENROLLED' named entity 'ACUTE' named entity 'COMPARED' named entity 'PANEL' named entity 'PERIOD' named entity 'BACTERIAL INFECTION' named entity 'VIRAL INFECTION' named entity 'CAUSED BY' named entity 'RESULTS' named entity 'HOSPITALIZED CHILDREN' named entity 'DURATION OF HOSPITALIZATION' named entity 'CLINICAL DATA' named entity 'UPPER' named entity 'VIRAL DETECTION' named entity 'TOTAL' named entity 'MULTIPLE' named entity 'VIRAL' named entity 'EVIDENCE OF' covid:arg/2480b2d6683049fbd9522d1b2e8dd1ea006fb122 named entity 'patients' named entity 'Virus' named entity 'clinical' named entity 'viral infection' named entity 'medical records'

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