About: A Plasma Biomarker Panel of Four MicroRNAs for the Diagnosis of Prostate Cancer

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Plasma Biomarker Panel of Four MicroRNAs for the Diagnosis of Prostate Cancer
Creator	Batra, Jyotsna Chambers, Suzanne Jeet, Varinder Matin, Farhana Moya, Leire Clements, Judith Bioresource, Selth, Luke
Source	Medline; PMC
abstract	Prostate cancer is diagnosed in over 1 million men every year globally, yet current diagnostic modalities are inadequate for identification of significant cancer and more reliable early diagnostic biomarkers are necessary for improved clinical management of prostate cancer patients. MicroRNAs (miRNAs) modulate important cellular processes/pathways contributing to cancer and are stably present in body fluids. In this study we profiled 372 cancer-associated miRNAs in plasma collected before (~60% patients) and after/during commencement of treatment (~40% patients), from age-matched prostate cancer patients and healthy controls, and observed elevated levels of 4 miRNAs - miR-4289, miR-326, miR-152-3p and miR-98-5p, which were validated in an independent cohort. The miRNA panel was able to differentiate between prostate cancer patients and controls (AUC = 0.88). Analysis of published miRNA transcriptomic data from clinical samples demonstrated low expression of miR-152-3p in tumour compared to adjacent non-malignant tissues. Overexpression of miR-152-3p increased proliferation and migration of prostate cancer cells, suggesting a role for this miRNA in prostate cancer pathogenesis, a concept that was supported by pathway analysis of predicted miR-152-3p target genes. In summary, a four miRNA panel, including miR-152-3p which likely targets genes with key roles in prostate cancer pathogenesis, has the potential to improve early prostate cancer diagnosis.
has issue date	2018-04-27(xsd:dateTime)
bibo:doi	10.1038/s41598-018-24424-w
bibo:pmid	29703916
has license	cc-by
sha1sum (hex)	247d7378386c4c48cf327c151a9ea73040df0403
schema:url	https://doi.org/10.1038/s41598-018-24424-w
resource representing a document's title	A Plasma Biomarker Panel of Four MicroRNAs for the Diagnosis of Prostate Cancer
has PubMed Central identifier	PMC5923293
has PubMed identifier	29703916
schema:publication	Sci Rep
resource representing a document's body	covid:247d7378386c4c48cf327c151a9ea73040df0403#body_text
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