About: Roles of transforming growth factor-β and phosphatidylinositol 3-kinase isoforms in integrin β1-mediated bio-behaviors of mouse lung telocytes

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Roles of transforming growth factor-β and phosphatidylinositol 3-kinase isoforms in integrin β1-mediated bio-behaviors of mouse lung telocytes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Roles of transforming growth factor-β and phosphatidylinositol 3-kinase isoforms in integrin β1-mediated bio-behaviors of mouse lung telocytes
Creator	Wang, Lu Tang, Li Wang, Xiangdong Zeng, Tao Song, Dongli Huang, Jianan
Source	PMC
abstract	BACKGROUND: Telocytes (TCs) have the capacity of cell–cell communication with adjacent cells within the tissue, contributing to tissue repair and recovery from injury. The present study aims at investigating the molecular mechanisms by which the TGFβ1-ITGB1-PI3K signal pathways regulate TC cycle and proliferation. METHODS: Gene expression of integrin (ITG) family were measured in mouse primary TCs to compare with other cells. TC proliferation, movement, cell cycle, and PI3K isoform protein genes were assayed in ITGB1-negative or positive mouse lung TCs treated with the inhibition of PI3Kp110α, PI3Kα/δ, PKCβ, or GSK3, followed by TGFβ1 treatment. RESULTS: We found the characters and interactions of ITG or PKC family member networks in primary mouse lung TCs, different from other cells in the lung tissue. The deletion of ITGB1 changed TCs sensitivity to treatment with multifunctional cytokines or signal pathway inhibitors. The compensatory mechanisms occur among TGFβ1-induced PI3Kp110α, PI3Kα/δ, PKCβ, or GSK3 when ITGB1 gene was deleted, leading to alterations of TC cell cycle and proliferation. Of those PI3K isoform protein genes, mRNA expression of PIK3CG altered with ITGB1-negative TC cycle and proliferation. CONCLUSION: TCs have strong capacity of proliferation through the compensatory signaling mechanisms and contribute to the development of drug resistance due to alterations of TC sensitivity.
has issue date	2019-12-30(xsd:dateTime)
bibo:doi	10.1186/s12967-019-02181-2
bibo:pmid	31888636
has license	cc-by
sha1sum (hex)	2404fe48477531d155dc0cb3e0028a49930280e6
schema:url	https://doi.org/10.1186/s12967-019-02181-2
resource representing a document's title	Roles of transforming growth factor-β and phosphatidylinositol 3-kinase isoforms in integrin β1-mediated bio-behaviors of mouse lung telocytes
has PubMed Central identifier	PMC6936066
has PubMed identifier	31888636
schema:publication	J Transl Med
resource representing a document's body	covid:2404fe48477531d155dc0cb3e0028a49930280e6#body_text
is schema:about of	named entity 'regulate' named entity 'signal' named entity 'tissue' named entity 'TGFβ1' named entity 'signal pathways' named entity 'phosphatidylinositol 3-kinase' named entity 'CD8' named entity 'Akt' named entity 'California' named entity 'GSK3β' named entity 'ITGB1' named entity 'GSK3β' named entity 'IBM' named entity 'gene expression' named entity 'TGFβ1' named entity 'PI3K' named entity 'cell proliferation' named entity 'PIK3CD' named entity 'mesenchymal stem cells' named entity 'TGFβ1' named entity 'TGFβ1' named entity 'ITG' named entity 'ITGB1' named entity 'Enzastaurin' named entity 'TGFβ1' named entity 'cell proliferation' named entity 'polymerase' named entity 'PI3K' named entity '450 nm' named entity 'PDGFR-α' named entity 'fibronectins' named entity 'lung' named entity 'ITGB1' named entity 'protein' named entity '5.0' named entity 'Enzastaurin' named entity 'PIK3CD' named entity 'PKCβ' named entity 'PI3K' named entity 'ITGB1' named entity 'GSK3' named entity 'PI3K' named entity 'Rap1' named entity 'cell-cell communication' named entity 'protein' named entity 'Protein Kinase' named entity 'TGFβ1' named entity 'isoform' named entity 'DNA damage' named entity 'PKC' named entity 'Enzastaurin' named entity 'cell proliferation' named entity 'beta1' named entity 'SPSS' named entity 'TGFβ1' named entity 'vimentin' named entity 'cell proliferation' named entity 'inflammation' named entity 'G1 phase' named entity 'TGFβ1' named entity 'ITG' named entity 'G1 phase' named entity 'PKCβ' named entity 'PIK3CA' named entity 'Molecular Devices' named entity 'PI3K' named entity 'ITGB1' named entity 'ITGB1' named entity 'over-expression' named entity 'PI3K' named entity 'phase-contrast microscope' named entity 'GSK' named entity 'fibroblasts' named entity 'PKC' named entity 'metastasis' named entity 'PIK3CA'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software