About: Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014

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About: Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014
Creator	Tong, Suxiang Haynes, Lia Metcalfe, Maureen Tao, Ying Zaki, Sherif Uyeki, Timothy Al Hosani, Farida Swerdlow, David Abdel-Wareth, Laila Barakat, Maha Gerber, Susan Alami, Negar Jones, Tara Keating, M Mutei, Mowafaq Ng, Dianna
Source	Elsevier; Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) infection causes an acute respiratory illness and is associated with a high case fatality rate; however, the pathogenesis of severe and fatal MERS-CoV infection is unknown. We describe the histopathologic, immunohistochemical, and ultrastructural findings from the first autopsy performed on a fatal case of MERS-CoV in the world, which was related to a hospital outbreak in the United Arab Emirates in April 2014. The main histopathologic finding in the lungs was diffuse alveolar damage. Evidence of chronic disease, including severe peripheral vascular disease, patchy cardiac fibrosis, and hepatic steatosis, was noted in the other organs. Double staining immunoassays that used anti–MERS-CoV antibodies paired with immunohistochemistry for cytokeratin and surfactant identified pneumocytes and epithelial syncytial cells as important targets of MERS-CoV antigen; double immunostaining with dipeptidyl peptidase 4 showed colocalization in scattered pneumocytes and syncytial cells. No evidence of extrapulmonary MERS-CoV antigens were detected, including the kidney. These results provide critical insights into the pathogenesis of MERS-CoV in humans.
has issue date	2016-03-31(xsd:dateTime)
bibo:doi	10.1016/j.ajpath.2015.10.024
bibo:pmid	26857507
has license	els-covid
sha1sum (hex)	23fbac9b3d8fd757900526382fb6b83dd6cc06f0
schema:url	https://doi.org/10.1016/j.ajpath.2015.10.024
resource representing a document's title	Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014
has PubMed Central identifier	PMC7093852
has PubMed identifier	26857507
schema:publication	The American Journal of Pathology
resource representing a document's body	covid:23fbac9b3d8fd757900526382fb6b83dd6cc06f0#body_text
is schema:about of	named entity 'UNITED ARAB EMIRATES' named entity 'CORONAVIRUS INFECTION' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'April' named entity 'CASE' named entity 'FATAL' named entity 'APRIL' named entity 'FINDINGS' named entity 'Ultrastructural' named entity 'United Arab Emirates' named entity 'Middle East Respiratory Syndrome' named entity 'Immunohistochemical' named entity 'Ultrastructural' named entity 'lymphopenia' named entity 'MERS-CoV' named entity 'pleural effusions' named entity 'trachea' named entity 'angiotensin-converting enzyme 2' named entity 'electron microscopy' named entity 'kidney' named entity 'basement membranes' named entity 'type 2' named entity 'Pathologic' named entity 'endothelium' named entity 'Illumina MiSeq' named entity 'hyaline' named entity 'submucosal glands' named entity 'DPP4' named entity '0.9' named entity 'case fatality rate' named entity 'receptor' named entity 'paraffin block' named entity 'MERS-CoV' named entity 'levofloxacin' named entity 'immunostaining' named entity 'pericardial effusion' named entity 'antigens' named entity 'lungs' named entity 'pneumonia' named entity 'oxygen' named entity 'angiotensin-converting enzyme 2' named entity 'histology' named entity 'infection' named entity 'immunohistochemical' named entity 'inotropic' named entity 'SARS-CoV' named entity 'MERS-CoV' named entity 'MERS-CoV' named entity 'pneumocytes' named entity 'hydrocortisone' named entity 'asymptomatic infection' named entity 'respiratory tract' named entity 'MERS-CoV' named entity 'hyphae' named entity 'infection' named entity 'prednisolone' named entity 'prednisolone' named entity 'rhinorrhea' named entity 'CDC' named entity 'lower respiratory tract' named entity 'Middle East respiratory syndrome coronavirus' named entity 'Kingdom of Saudi Arabia' named entity 'immunohistochemistry' named entity 'dialysis' named entity 'MERS-CoV' named entity 'crackles'

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