About: Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

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About: Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
Creator	Huang, Yi Li, Wenhui He, Wenhui Qi, Yonghe Sui, Jianhua Sun, Yinyan Zhong, Guocai Feng, Xiaofeng Chen, Pan Cai, Tao Fu, Liran Gao, Wenqing Gao, Zhenchao Jing, Zhiyi Peng, Bo Ren, Bijie Song, Mei Wang, Haimin Xu, Guangwei Yan, Huan
Source	PMC
abstract	Human hepatitis B virus (HBV) infection and HBV-related diseases remain a major public health problem. Individuals coinfected with its satellite hepatitis D virus (HDV) have more severe disease. Cellular entry of both viruses is mediated by HBV envelope proteins. The pre-S1 domain of the large envelope protein is a key determinant for receptor(s) binding. However, the identity of the receptor(s) is unknown. Here, by using near zero distance photo-cross-linking and tandem affinity purification, we revealed that the receptor-binding region of pre-S1 specifically interacts with sodium taurocholate cotransporting polypeptide (NTCP), a multiple transmembrane transporter predominantly expressed in the liver. Silencing NTCP inhibited HBV and HDV infection, while exogenous NTCP expression rendered nonsusceptible hepatocarcinoma cells susceptible to these viral infections. Moreover, replacing amino acids 157–165 of nonfunctional monkey NTCP with the human counterpart conferred its ability in supporting both viral infections. Our results demonstrate that NTCP is a functional receptor for HBV and HDV. DOI: http://dx.doi.org/10.7554/eLife.00049.001
has issue date	2012-11-13(xsd:dateTime)
bibo:doi	10.7554/elife.00049
bibo:pmid	23150796
has license	cc-by
sha1sum (hex)	23d8bce7be2d5afed730addd3b4531f1bc721da6
schema:url	https://doi.org/10.7554/elife.00049
resource representing a document's title	Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
has PubMed Central identifier	PMC3485615
has PubMed identifier	23150796
schema:publication	eLife
resource representing a document's body	covid:23d8bce7be2d5afed730addd3b4531f1bc721da6#body_text
is schema:about of	named entity 'hepatitis B virus' named entity 'determinant' named entity 'number' named entity 'HDV' named entity 'Silencing' named entity '2007' covid:arg/23d8bce7be2d5afed730addd3b4531f1bc721da6 named entity 'determinant' named entity 'HBV' named entity '2009' named entity 'coinfected' named entity 'receptor' named entity 'receptor' named entity 'HDV' named entity 'human' named entity 'envelope proteins' named entity 'HDV' named entity 'infection' named entity 'hepatocarcinoma' named entity 'HBV' named entity 'HBV' named entity 'transmembrane transporter' named entity 'cellular receptor' named entity 'HDV' named entity 'NTCP' named entity 'receptor' named entity 'polypeptide' named entity 'mAb' named entity 'infection' named entity 'protein sequences' named entity 'covalently' named entity 'NTCP' named entity 'cccDNA' named entity 'transfected' named entity 'RNA genome' named entity 'immunogen' named entity 'siRNA' named entity 'fetal bovine serum' named entity 'RNA' named entity 'liver' named entity 'Peptides' named entity 'HBV' named entity 'siRNA' named entity 'amino acids' named entity 'transfected' named entity 'genome' named entity 'receptor' named entity 'Paraformaldehyde' named entity 'virus' named entity 'NTCP' named entity 'transfected' named entity 'antigen' named entity 'HBV' named entity 'transcriptome' named entity 'milliliter' named entity 'detection limit' named entity 'liver cirrhosis' named entity '2D3' named entity 'peptide' named entity 'HDV' named entity 'phenylalanine' named entity 'NTCP'

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