About: Investigating Viral Interference Between Influenza A Virus and Human Respiratory Syncytial Virus in a Ferret Model of Infection

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About: Investigating Viral Interference Between Influenza A Virus and Human Respiratory Syncytial Virus in a Ferret Model of Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Investigating Viral Interference Between Influenza A Virus and Human Respiratory Syncytial Virus in a Ferret Model of Infection
Creator	Barr, Ian Druce, Julian Reading, Patrick Carolan, Louise Chan, Laurie, Karen Mccaw, James Kok, Fei Korenkov, Daniil
Source	PMC
abstract	Epidemiological studies have observed that the seasonal peak incidence of influenza virus infection is sometimes separate from the peak incidence of human respiratory syncytial virus (hRSV) infection, with the peak incidence of hRSV infection delayed. This is proposed to be due to viral interference, whereby infection with one virus prevents or delays infection with a different virus. We investigated viral interference between hRSV and 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) in the ferret model. Infection with A(H1N1)pdm09 prevented subsequent infection with hRSV. Infection with hRSV reduced morbidity attributed to infection with A(H1N1)pdm09 but not infection, even when an increased inoculum dose of hRSV was used. Notably, infection with A(H1N1)pdm09 induced higher levels of proinflammatory cytokines, chemokines, and immune mediators in the ferret than hRSV. Minimal cross-reactive serological responses or interferon γ–expressing cells were induced by either virus ≥14 days after infection. These data indicate that antigen-independent mechanisms may drive viral interference between unrelated respiratory viruses that can limit subsequent infection or disease.
has issue date	2018-08-01(xsd:dateTime)
bibo:doi	10.1093/infdis/jiy184
bibo:pmid	29746640
has license	no-cc
sha1sum (hex)	23bbfb7ade437b0b4dc099de491a37024c45288d
schema:url	https://doi.org/10.1093/infdis/jiy184
resource representing a document's title	Investigating Viral Interference Between Influenza A Virus and Human Respiratory Syncytial Virus in a Ferret Model of Infection
has PubMed Central identifier	PMC7107400
has PubMed identifier	29746640
schema:publication	J Infect Dis
resource representing a document's body	covid:23bbfb7ade437b0b4dc099de491a37024c45288d#body_text
is schema:about of	named entity 'HUMAN RESPIRATORY SYNCYTIAL VIRUS' named entity 'REDUCED' named entity 'RESPONSES' named entity 'INDEPENDENT' named entity 'PEAK' named entity 'CROSS-REACTIVE' named entity 'INCIDENCE' named entity 'SEROLOGICAL' named entity 'MECHANISMS' named entity '28A' named entity 'SEPARATE' named entity 'DISEASE' named entity 'FERRET' named entity 'DELAYED' named entity 'infection' named entity 'viral' named entity 'drive' named entity 'model' named entity 'virus' named entity 'dose' named entity 'attributed' named entity 'FERRET' covid:arg/23bbfb7ade437b0b4dc099de491a37024c45288d named entity 'VIRUS INFECTION' named entity 'IMMUNE MEDIATORS' named entity 'THE PEAK' named entity 'EPIDEMIOLOGICAL STUDIES' named entity 'INOCULUM' named entity 'UNRELATED' named entity 'PREVENTS' named entity 'LEVELS' named entity 'DIFFERENT' named entity 'INFECTION' named entity 'INCREASED' named entity 'PANDEMIC' named entity 'OBSERVED' named entity 'HIGHER' named entity 'INFECTION' named entity 'DATA' named entity 'HRSV' named entity 'DUE TO' named entity 'RESPIRATORY VIRUSES' named entity 'THESE' named entity 'VIRAL INTERFERENCE' named entity 'PROPOSED' named entity 'DOSE' named entity 'CELLS' named entity 'INFLUENZA A VIRUS' named entity 'INVESTIGATING' named entity 'VIRAL INTERFERENCE' named entity 'USED' named entity 'LIMIT' named entity 'SUBSEQUENT' named entity 'INTERFERON ' named entity 'INDUCED' named entity 'DRIVE' named entity 'INFLUENZA A' named entity 'MODEL OF' named entity 'VIRUS' named entity 'DAYS' named entity 'HUMAN RESPIRATORY SYNCYTIAL VIRUS' named entity 'SEASONAL' named entity 'HAVE' named entity 'INFLUENZA VIRUS' named entity 'MODEL' named entity 'MINIMAL' named entity 'INVESTIGATED' named entity 'BUT' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'MORBIDITY' named entity 'CHEMOKINES' named entity 'EITHER' named entity 'ANTIGEN'

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