About: Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents

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About: Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents
Creator	Pannecouque, Christophe Claessens, Frank Dehaen, Wim Helsen, Christine Karypidou, Konstantina Persoons, Leentje Quevedo, Mario Ribone, Sergio
source	Elsevier; Medline; PMC
abstract	Synthesis and biological evaluation of a novel library of fused 1,2,3-triazole derivatives are described. The in-house developed multicomponent reaction based on commercially available starting materials was applied and broad biological screening against various viruses was performed, showing promising antiviral properties for compounds 14d, 14n, 14q, 18f and 18i against human coronavirus 229E. Further in silico studies identified the key molecular interactions between those compounds and the 3-chymotrypsin-like protease, which is essential to the intracellular replication of the virus, supporting the hypothesis that the protease is the target molecule of the potential antiviral derivatives.
has issue date	2018-11-15(xsd:dateTime)
bibo:doi	10.1016/j.bmcl.2018.09.019
bibo:pmid	30286952
has license	no-cc
sha1sum (hex)	23b70503c8994ce96f951852804e514ac5833dfd
schema:url	https://doi.org/10.1016/j.bmcl.2018.09.019
resource representing a document's title	Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents
has PubMed Central identifier	PMC7127349
has PubMed identifier	30286952
schema:publication	Bioorg Med Chem Lett
resource representing a document's body	covid:23b70503c8994ce96f951852804e514ac5833dfd#body_text
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