About: Dysregulation of immune response in patients with COVID-19 in Wuhan, China

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About: Dysregulation of immune response in patients with COVID-19 in Wuhan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dysregulation of immune response in patients with COVID-19 in Wuhan, China
Creator	Wang, Wei Qin, Chuan Hu, Ziwei Ma, Ke Shang, Ke Tao, Yu Tian, Dai-Shi Yang, Sheng Zhang, Shuoqi Zhou, Luoqi Tian, Dai-Shi,
Source	Medline; PMC
abstract	BACKGROUND: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread throughout China. METHODS: Demographic and clinical data of all confirmed cases with COVID-19 on admission at Tongji Hospital from January 10 to February 12, 2020, were collected and analyzed. The data of laboratory examinations, including peripheral lymphocyte subsets, were analyzed and compared between severe and non-severe patients. RESULTS: Of the 452 patients with COVID-19 recruited, 286 were diagnosed as severe infection. The median age was 58 years and 235 were male. The most common symptoms were fever, shortness of breath, expectoration, fatigue, dry cough and myalgia. Severe cases tend to have lower lymphocytes counts, higher leukocytes counts and neutrophil-lymphocyte-ratio (NLR), as well as lower percentages of monocytes, eosinophils, and basophils. Most of severe cases demonstrated elevated levels of infection-related biomarkers and inflammatory cytokines. The number of T cells significantly decreased, and more hampered in severe cases. Both helper T cells and suppressor T cells in patients with COVID-19 were below normal levels, and lower level of helper T cells in severe group. The percentage of naïve helper T cells increased and memory helper T cells decreased in severe cases. Patients with COVID-19 also have lower level of regulatory T cells, and more obviously damaged in severe cases. CONCLUSIONS: The novel coronavirus might mainly act on lymphocytes, especially T lymphocytes. Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis and treatment of COVID-19.
has issue date	2020-03-12(xsd:dateTime)
bibo:doi	10.1093/cid/ciaa248
bibo:pmid	32161940
has license	no-cc
sha1sum (hex)	2369adf9ae01de1ff19ee2b39c7e253e484d1459
schema:url	https://doi.org/10.1093/cid/ciaa248
resource representing a document's title	Dysregulation of immune response in patients with COVID-19 in Wuhan, China
has PubMed Central identifier	PMC7108125
has PubMed identifier	32161940
schema:publication	Clin Infect Dis
resource representing a document's body	covid:2369adf9ae01de1ff19ee2b39c7e253e484d1459#body_text
is schema:about of	named entity 'severe' named entity 'PATIENTS' covid:arg/2369adf9ae01de1ff19ee2b39c7e253e484d1459 named entity 'COVID-19' named entity 'PERIPHERAL' named entity 'INCLUDING' named entity 'ANALYZED' named entity 'PATIENTS' named entity 'COLLECTED' named entity 'LYMPHOCYTE SUBSETS' named entity 'NON-' named entity 'SEVERE' named entity 'LABORATORY' named entity 'IMMUNE RESPONSE' named entity 'WUHAN' named entity 'CHINA' named entity 'EXAMINATIONS' named entity 'DATA' named entity 'COMPARED' named entity 'laboratory' named entity 'COVID-19' named entity 'Dysregulation' named entity 'COVID' named entity 'self-tolerance' named entity 'COVID-19' named entity 'COVID-19' named entity 'serum' named entity 'regulatory T cells' named entity 'inflammatory cytokines' named entity 'host immune responses' named entity 'informed consent' named entity 'PCR' named entity 'coronavirus disease 2019' named entity 'inflammation' named entity 'FiO2' named entity 'COVID-19' named entity 'pneumonia' named entity 'infection' named entity 'χ2 test' named entity 'China' named entity 'hypertension' named entity 'positive test' named entity 'lymphocyte' named entity '11.6' named entity 'medical record' named entity 'infection' named entity 'peripheral blood' named entity 'CD4+' named entity 'P-values' named entity 'SARS-CoV-2' named entity 'central China' named entity 'lymphocytes' named entity 'reference limit' named entity 'COVID-19' named entity 'chemokine' named entity 'lymphopenia' named entity 'World Health Organization' named entity 'inflammatory responses' named entity 'COVID-19' named entity 'COVID' named entity 'Coronavirus' named entity 'virus infections' named entity 'partial pressure' named entity 'China' named entity 'IL-6' named entity 'COVID' named entity 'COVID' named entity '5.6' named entity 'IgM' named entity 'monocytes'

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