About: Declining SARS-CoV-2 PCR sensitivity with time and dependence on clinical features: consequences for control

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Declining SARS-CoV-2 PCR sensitivity with time and dependence on clinical features: consequences for control
Creator	Reusken, C De Vries, E Bergmans, B Berrevoets, M Bonačić Marinović, A Godeke, G Kluiters-De Hingh, Y Murk, J Nieman, A Reimerink, J Swart2, A Van Oudheusden, A Verweij, J Vingerhoets, R
Source	MedRxiv
abstract	Real-time reverse transcription-polymerase chain reaction (RT-PCR) on upper respiratory tract (URT) samples is the primary method to diagnose SARS-CoV-2 infections and guide public health measures, with a supportive role for serology. However, the clinical sensitivity of RT-PCR remains uncertain. In the present study, Bayesian statistical modeling was used to retrospectively determine the sensitivity of RT-PCR using SARS-CoV-2 serology in 644 COVID-19-suspected patients with varying degrees of disease severity and duration. The sensitivity of RT-PCR ranged between 79-95%; while increasing with disease severity, it decreased rapidly over time in mild COVID-19 cases. Negative URT RT-PCR results should therefore be interpreted in the context of clinical characteristics, especially with regard to containment of viral transmission based on the 'test, trace and isolate' principle.
has issue date	2020-08-25(xsd:dateTime)
bibo:doi	10.1101/2020.08.23.20179408
has license	medrxiv
sha1sum (hex)	235782ffea953ddbec5718075375b9cded0896eb
schema:url	https://doi.org/10.1101/2020.08.23.20179408
resource representing a document's title	Declining SARS-CoV-2 PCR sensitivity with time and dependence on clinical features: consequences for control
resource representing a document's body	covid:235782ffea953ddbec5718075375b9cded0896eb#body_text
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