About: Diagnosis, Outcome, and Management of Chylous Ascites Following Pediatric Liver Transplantation

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About: Diagnosis, Outcome, and Management of Chylous Ascites Following Pediatric Liver Transplantation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Diagnosis, Outcome, and Management of Chylous Ascites Following Pediatric Liver Transplantation
Creator	Grant, David Ghanekar, Anand Avitzur, Yaron Cattral, Mark Levman, Aviva Lurz, Eberhard Miserachs, Mar Ng, Vicky
Source	Medline; PMC
abstract	Data on postoperative chylous ascites (CA) after pediatric liver transplantation (LT) are scarce. This retrospective study was conducted to identify the incidence, risk factors, management, and outcomes of postoperative CA in a large single‐center pediatric LT cohort (2000‐2016). The study cohort comprised 317 LTs (153 living donors and 164 deceased donors) in 310 recipients with a median age of 2.7 years. The incidence of CA was 5.4% (n = 17), diagnosed after a median time of 10 days after LT. Compared with chylomicron detection in peritoneal fluid (the gold standard), a triglyceride cutoff value of 187 mg/dL in peritoneal fluid showed insufficient sensitivity (31%) for CA diagnosis. In univariate logistic regression analyses, ascites before LT, younger age, and lower weight, height, and height‐for‐age z score at LT were associated with CA. Symptomatic management of CA included peritoneal drain (100%) and diuretics (76%). Therapeutic interventions included very low‐fat or medium‐chain triglyceride–rich diets (94%) and intravenous octreotide (6%), leading to CA resolution in all patients. CA was associated with prolonged hospital length of stay (LOS; 40 days in the CA group versus 24 days in the non‐CA group; P = 0.001) but not with reduced patient or graft survival rates after a median follow‐up time of 14 years. In conclusion, CA in the pediatric LT recipient is a relatively uncommon complication associated with increased hospital LOS and morbidity. Measurement of chylomicrons is recommended in patients with ascites that is more severe or persistent than expected. Dietary interventions are effective in most patients.
has issue date	2019-08-06(xsd:dateTime)
bibo:doi	10.1002/lt.25604
bibo:pmid	31301267
has license	no-cc
sha1sum (hex)	231b9cf512e3aad52f61bd2754bd1737ed356b32
schema:url	https://doi.org/10.1002/lt.25604
resource representing a document's title	Diagnosis, Outcome, and Management of Chylous Ascites Following Pediatric Liver Transplantation
has PubMed Central identifier	PMC7165704
has PubMed identifier	31301267
schema:publication	Liver Transpl
resource representing a document's body	covid:231b9cf512e3aad52f61bd2754bd1737ed356b32#body_text
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