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About:
Impact of Preexisting Circulating Effector T cells on the Outcome of ABO-Incompatible Adult LDLT
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An Entity of Type :
schema:ScholarlyArticle
, within Data Space :
covidontheweb.inria.fr
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document(s)
Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Impact of Preexisting Circulating Effector T cells on the Outcome of ABO-Incompatible Adult LDLT
Creator
Kenji, A
Yasuhiro, A
Ae, Kaido
Ae, Kasahara
Ae, Masako
Ae, Ogura
Ae, Ozawa
Ae, Takai
Ae, Teramukai
Egawa, Hiroto
Kazue, A
Mori, Akira
Mureo, A
Ogawa, Kohei
Oike, Fumitaka
Sato, Hiroshi
Satoshi, A
Takada, Yasutsugu
Toshimi, A
Uemoto, Shinji
Source
PMC
abstract
Our aim was to clarify the significance of phenotype of circulating CD8 T(+) cells on the outcome of ABO-incompatible (ABO-I) living donor liver transplantation (LDLT). Twenty-six recipients undergoing ABO-I LDLT and 92 undergoing ABO-compatible (ABO-C) LDLT were classified into three groups according to preoperative proportion of CD8 T(+) cells: naive-dominant (group I), effector memory-dominant (group II), and effector-dominant (group III) recipients. The clinical courses were analyzed. The results showed that in ABO-C groups I and II and in ABO-I group I, effector cells remained above the pretransplant levels after tacrolimus administration. However, in ABO-C group III and ABO-I groups II and III, effector cells were down-regulated for a prolonged period, along with markedly decreased perforin expression and frequent life-threatening complications. ABO-I group II and group III recipients had higher infection rates. It was concluded that recipients with preexisting high effector CD8 T(+) cells are unfavorable candidates for ABO-I LDLT.
has issue date
2008-12-11
(
xsd:dateTime
)
bibo:doi
10.1007/s10620-008-0618-y
bibo:pmid
19082716
has license
no-cc
sha1sum (hex)
230cce33d6f272e8061dd59bb01726df90c515bc
schema:url
https://doi.org/10.1007/s10620-008-0618-y
resource representing a document's title
Impact of Preexisting Circulating Effector T cells on the Outcome of ABO-Incompatible Adult LDLT
has PubMed Central identifier
PMC7102009
has PubMed identifier
19082716
schema:publication
Dig Dis Sci
resource representing a document's body
covid:230cce33d6f272e8061dd59bb01726df90c515bc#body_text
is
schema:about
of
named entity 'However'
named entity 'RATES'
named entity 'I GROUP'
named entity 'PROPORTION'
named entity 'GROUPS'
named entity 'DOWN-REGULATED'
named entity 'LIFE'
named entity 'PHENOTYPE'
named entity 'OUR'
named entity 'ABO'
named entity 'LEVELS'
named entity 'CD8'
named entity 'PREEXISTING'
named entity 'TACROLIMUS'
named entity 'groups'
named entity 'proportion'
named entity 'Our'
named entity 'group I'
named entity 'Adult'
named entity 'phenotype'
named entity 'perforin'
named entity 'CD8'
named entity 'effector cells'
named entity 'effector cells'
named entity 'CD8'
named entity 'effector'
named entity 'effector'
named entity 'LDLT'
named entity 'life-threatening'
named entity 'perforin'
named entity 'down-regulation'
named entity 'CD8'
named entity 'Effector'
named entity 'phenotypic'
named entity 'bile duct'
named entity 'CD27'
named entity 'Prostaglandin E1'
named entity 'significant difference'
named entity 'infection'
named entity 'allograft'
named entity 'CTL'
named entity 'intravenous'
named entity 'effector T cells'
named entity 'CD8'
named entity 'cytotoxic'
named entity 'Kyoto University'
named entity 'effector'
named entity 'hepatocellular carcinoma'
named entity 'phenotype'
named entity 'CD8'
named entity 'effector T cells'
named entity 'PVI'
named entity 'ABO'
named entity 'San Diego'
named entity 'pathogens'
named entity 'effector T cells'
named entity 'prophylaxis'
named entity 'hepatic artery'
named entity 'antibody-mediated'
named entity 'ABO'
named entity 'CD8'
named entity 'ABO'
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