About: COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis

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About: COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis
Creator	Zambon, Maria Charlett, Andre Letley, Louise Boddington, Nicola Bennett, Emma Mcmenamin, Jim Douglas, Ian Cottrell, Simon Coughlan, Laura Dabrera, Gavin Edeghere, Obaghe Lopez Bernal, Jamie Mansfield, Kathryn Mathur, Rohini Mcdonald, Helen Panagiotopoulos, Nikolaos Ramsay, Mary Sinnathamby, Mary Walker, Jemma Rentsch, Christopher Shingleton, Joseph Byers, Chloe Elgohari, Suzanne Garcia Vilaplana, Tatiana Grint, Daniel Macdonald, Pauline Minassian, Caroline Peppa, Maria Saliba, Vanessa Strongman, Helen Vivancos, Roberto Whillock, Rosie
topic	covid:22bda59afecdaa523e9221f0bbbe88dbd4ff0636#this
source	MedRxiv
abstract	Objectives: Following detection of the first virologically-confirmed cases of COVID-19 in Great Britain, an enhanced surveillance study was initiated by Public Health England to describe the clinical presentation, course of disease and identify risk factors for infection of the first few hundred cases. Methods: Information was collected on the first COVID-19 cases according to the First Few X WHO protocol. Case-control analyses of the sensitivity, specificity and predictive value of symptoms and risk factors for infection were conducted. Point prevalences of underlying health conditions among the UK general population were presented. Findings: The majority of FF100 cases were imported (51.4%), of which the majority had recent travel to Italy (71.4%). 24.7% were secondary cases acquired mainly through household contact (40.4%). Children had lower odds of COVID-19 infection compared with the general population. The clinical presentation of cases was dominated by cough, fever and fatigue. Non-linear relationships with age were observed for fever, and sensitivity and specificity of symptoms varied by age. Conditions associated with higher odds of COVID-19 infection (after adjusting for age and sex) were chronic heart disease, immunosuppression and multimorbidity. Conclusion: This study presents the first epidemiological and clinical summary of COVID-19 cases in Great Britain. The FFX study design enabled systematic data collection. The study was able to characterize the risk factors for infection with population prevalence estimates setting these relative risks into a public health context. It also provides important evidence for generating case definitions to support public health risk assessment, clinical triage and diagnostic algorithms.
has issue date	2020-05-22(xsd:dateTime)
bibo:doi	10.1101/2020.05.18.20086157
has license	medrxiv
sha1sum (hex)	22bda59afecdaa523e9221f0bbbe88dbd4ff0636
schema:url	https://doi.org/10.1101/2020.05.18.20086157
resource representing a document's title	COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis
resource representing a document's body	covid:22bda59afecdaa523e9221f0bbbe88dbd4ff0636#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/22bda59afecdaa523e9221f0bbbe88dbd4ff0636
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