About: Recent advances in peptide chain termination

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Recent advances in peptide chain termination
Creator	Lee, C Caskey, C Craigen, W
Source	Medline; PMC
abstract	Peptide chain termination occurs when a stop codon is decoded by a release factor. In Escherichia coli two codon‐specific release factors (RF1 and RF2) direct the termination of protein synthesis, while in eukaryotes a single factor is required. The E. coli factors have been purified and their genes isolated. A combination of protein and DNA sequence data reveal that the RFs are structurally similar and that RF2 is encoded in two reading frames. Frame‐shifting from one reading frame to the next occurs at a rate of 50%, is regulated by the RF2‐specific stop codon UGA, and involves the direct interaction of the RF2 mRNA with the 3’end of the 16S rRNA. The RF genes are located in two separate operons, with the RF1 gene located at 26.7 min and the RF2 gene at 62.3 min on the chromosome map. Ribosomal binding studies place the RF‐binding region at the interface between the ribosomal subunits. A possible mechanism of stop‐codon recognition is reviewed.
has issue date	2006-10-27(xsd:dateTime)
bibo:doi	10.1111/j.1365-2958.1990.tb00658.x
bibo:pmid	2215213
has license	no-cc
sha1sum (hex)	22bc79af83af79082161f68edad263def3ae3cd6
schema:url	https://doi.org/10.1111/j.1365-2958.1990.tb00658.x
resource representing a document's title	Recent advances in peptide chain termination
has PubMed Central identifier	PMC7168415
has PubMed identifier	2215213
schema:publication	Mol Microbiol
resource representing a document's body	covid:22bc79af83af79082161f68edad263def3ae3cd6#body_text
is schema:about of	named entity 'gene' named entity 'chromosome map' named entity 'purified' named entity 'MIN' named entity 'REQUIRED' named entity 'RIBOSOMAL' named entity 'E. COLI' named entity 'FRAME' named entity 'binding' named entity 'specific' named entity 'ribosomal' named entity 'codon' named entity 'gene' named entity 'sense codon' named entity 'stop-codon' named entity 'UGA' named entity 'termination' named entity 'release' named entity 'chain termination' named entity 'Recent' named entity 'protein' named entity 'eukaryotes' named entity 'structurally similar' named entity 'protein synthesis' named entity '16S rRNA' named entity 'DNA sequence data' named entity 'stop-codon' named entity 'gene' named entity 'operons' named entity 'stop codon' named entity 'DNA sequence' named entity 'RFs' named entity 'assay' named entity 'large subunit' named entity 'chromosome map' named entity 'RFs' named entity 'f-met' named entity 'ribosome' named entity '16S rRNA' named entity 'peptidyl-transferase' named entity 'carbohydrate' named entity 'plasmid' named entity 'protein' named entity 'UGA' named entity 'euKaryotic genes' named entity 'RNA' named entity 'phage' named entity 'ribosomes' named entity 'hydrolysis' named entity 'ribosomal proteins' named entity 'stop-codon' named entity 'tRNA synthetase' named entity 'bacteria' named entity 'codon' named entity 'sense codon' named entity 'rat' named entity 'precipitation' named entity 'stop codon' named entity 'assay' named entity 'peptide' named entity '3'-end' named entity 'RFs' named entity 'cross-linked' named entity 'leader peptide' named entity 'codon' named entity 'termination reaction' named entity '16S rRNA' named entity 'Transcription' named entity 'L10' named entity 'gene' named entity 'operon' named entity 'ribosomal proteins' named entity 'chromosome map' named entity 'guanine nucleotides' named entity 'stop codon' named entity 'stop-codon' named entity 'gene' named entity 'divergent evolution' named entity 'UGA'

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