About: Genomic epidemiology of SARS-CoV-2 spread in Scotland highlights the role of European travel in COVID-19 emergence

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About: Genomic epidemiology of SARS-CoV-2 spread in Scotland highlights the role of European travel in COVID-19 emergence Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genomic epidemiology of SARS-CoV-2 spread in Scotland highlights the role of European travel in COVID-19 emergence
Creator	Rambaut, Andrew Palmarini, Massimo Ho, Antonia Tong, Lily Gunson, Rory Templeton, Kate Niebel, Marc Smollett, Katherine Holden, Matthew Maclean, Alasdair Orton, Richard Robertson, David Williams, Thomas Mchugh, Martin Leitch, Mcwilliam Aranday-Cortes, Elihu Hughes, Joseph Johnson, Natasha Mair, Daniel Shah, Rajiv Singer, Joshua Wastnedge, Elizabeth Asamaphan, Patawee Balcazar, Carlos Brunker, Kirstyn Carmichael, Stephen Carol, E Da, Ana Dewar, Rebecca Filipe, Silva Gallagher, Michael Jesudason, Natasha Li, Kathy Mcdonald, Sarah Nichols, Jenna O'toole, Áine Nomikou, Kyriaki Parr, Yasmin Rooke, Stefan Shaaban, Sharif Shepherd, James Starinskij, Igor Thomson, Emma Vattipally, Sreenu
Source	MedRxiv
abstract	Abstract SARS-CoV-2, the causative agent of COVID-19, emerged in Wuhan, China in December 2019 and spread rapidly throughout the world. Understanding the introductions of this new coronavirus in different settings may assist control efforts and the establishment of frameworks to support rapid response in future infectious disease outbreaks. We investigated the first four weeks of emergence of the SARS-CoV-2 virus in Scotland after the first case reported on the 1st March 2020. We obtained full genome sequences from 452 individuals with a laboratory-confirmed diagnosis of COVID-19, representing 20% of all cases until 1st April 2020 (n=2310). This permitted a genomic epidemiology approach to study the introductions and spread of the SARS-2 virus in Scotland. From combined phylogenetic and epidemiological analysis, we estimated at least 113 introductions of SARS-CoV-2 into Scotland during this period. Clusters containing multiple sequences suggestive of onward transmission occurred in 48/86 (56%). 42/86 (51%) clusters had no known international travel history indicating undetected introductions. The majority of viral sequences were most closely related to those circulating in other European countries, including Italy, Austria and Spain. Travel-associated introductions of SARS-CoV-2 into Scotland predated travel restrictions in the UK and other European countries. The first local transmission occurred three days after the first case. A shift from travel-associated to sustained community transmission was apparent after only 11 days. Undetected introductions occurred prior to the first known case of COVID-19. Earlier travel restrictions and quarantine measures might have resulted in fewer introductions into Scotland, thereby reducing the number of cases and the subsequent burden on health services. The high number of introductions and transmission rates were likely to have impacted on national contact tracing efforts. Our results also demonstrate that local real-time genomic epidemiology can be used to monitor transmission clusters and facilitate control efforts to restrict the spread of COVID-19.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1101/2020.06.08.20124834
has license	medrxiv
sha1sum (hex)	22a15238a8f8295f224d81ee0e1452588eedbc94
schema:url	https://doi.org/10.1101/2020.06.08.20124834
resource representing a document's title	Genomic epidemiology of SARS-CoV-2 spread in Scotland highlights the role of European travel in COVID-19 emergence
resource representing a document's body	covid:22a15238a8f8295f224d81ee0e1452588eedbc94#body_text
is schema:about of	named entity 'outbreak' named entity 'hospital' named entity 'Scotland' named entity 'admissions' named entity 'MONTH' named entity 'SOURCE' named entity 'RESPIRATORY SYSTEM' named entity 'DETECTED' named entity 'CHINA' named entity 'SCOTLAND' named entity 'ROLE' named entity 'GENOMIC EPIDEMIOLOGY' named entity 'SCOTLAND' named entity 'acute' named entity '2019' named entity 'causative' named entity 'Scotland' named entity 'December 2019' named entity 'Scotland' named entity 'SARS-CoV-2' named entity 'Scotland' named entity 'SARS-CoV-2' named entity 'Caribbean' named entity 'SARS-CoV-2' named entity 'France' named entity 'Italy' named entity 'virus' named entity 'Scotland' named entity 'Scotland' named entity 'epidemiological' named entity 'Glasgow' named entity 'GISAID' named entity 'phylogenetic signal' named entity 'global COVID-19 pandemic' named entity 'phylogenetic' named entity 'COVID-19 outbreak' named entity 'community transmission' named entity 'cluster analysis' named entity 'phylogenetic' named entity 'England' named entity 'peer review' named entity 'RNA virus'

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