About: Long-Term Single-Dose Efficacy of a Vesicular Stomatitis Virus-Based Andes Virus Vaccine in Syrian Hamsters

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About: Long-Term Single-Dose Efficacy of a Vesicular Stomatitis Virus-Based Andes Virus Vaccine in Syrian Hamsters Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Long-Term Single-Dose Efficacy of a Vesicular Stomatitis Virus-Based Andes Virus Vaccine in Syrian Hamsters
Creator	Feldmann, Heinz Prescott, Joseph Brown, Kyle Debuysscher, Blair
topic	covid:22977df2b5a35dfe536faa4bd77a21ab316dc9f8#this
Source	Medline; PMC
abstract	Andes virus (ANDV) is highly pathogenic in humans and is the primary etiologic agent of hantavirus cardiopulmonary syndrome (HCPS) in South America. Case-fatality rates are as high as 50% and there are no approved vaccines or specific therapies for infection. Our laboratory has recently developed a replication-competent recombinant vesicular stomatitis virus (VSV)-based vaccine that expressed the glycoproteins of Andes virus in place of the native VSV glycoprotein (G). This vaccine is highly efficacious in the Syrian hamster model of HCPS when given 28 days before challenge with ANDV, or when given around the time of challenge (peri-exposure), and even protects when administered post-exposure. Herein, we sought to test the durability of the immune response to a single dose of this vaccine in Syrian hamsters. This vaccine was efficacious in hamsters challenged intranasally with ANDV 6 months after vaccination (p = 0.025), but animals were not significantly protected following 1 year of vaccination (p = 0.090). The decrease in protection correlated with a reduction of measurable neutralizing antibody responses, and suggests that a more robust vaccination schedule might be required to provide long-term immunity.
has issue date	2014-01-31(xsd:dateTime)
bibo:doi	10.3390/v6020516
bibo:pmid	24492621
has license	cc-by
sha1sum (hex)	22977df2b5a35dfe536faa4bd77a21ab316dc9f8
schema:url	https://doi.org/10.3390/v6020516
resource representing a document's title	Long-Term Single-Dose Efficacy of a Vesicular Stomatitis Virus-Based Andes Virus Vaccine in Syrian Hamsters
has PubMed Central identifier	PMC3939469
has PubMed identifier	24492621
schema:publication	Viruses
resource representing a document's body	covid:22977df2b5a35dfe536faa4bd77a21ab316dc9f8#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/22977df2b5a35dfe536faa4bd77a21ab316dc9f8
is schema:about of	named entity 'ANDES VIRUS' named entity 'measurable' named entity 'hantavirus cardiopulmonary syndrome' named entity 'native' named entity 'EFFICACY' named entity '0.025' named entity 'RECOMBINANT' named entity 'CASE' named entity 'SOUTH AMERICA' named entity 'RESPONSE TO' named entity 'SYRIAN HAMSTER' named entity 'NATIVE' named entity 'LONG-TERM' named entity 'BUT' named entity 'OUR' named entity 'GIVEN' named entity 'TO TEST' named entity 'SPECIFIC' named entity 'LABORATORY' named entity 'VACCINES' named entity 'POST' named entity 'CHALLENGE' named entity 'REDUCTION' named entity 'GLYCOPROTEINS' named entity 'MIGHT BE' named entity 'RESPONSES' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'BASED' named entity '28P' named entity 'HUMANS' named entity 'NEUTRALIZING ANTIBODY' named entity 'HAMSTERS' named entity 'SYRIAN HAMSTERS' named entity 'DOSE' named entity 'VIRUS VACCINE' named entity 'TIME' named entity 'VACCINATION' named entity 'LONG-TERM' named entity 'ANIMALS' named entity 'SYRIAN HAMSTERS' named entity 'APPROVED' named entity 'DOSE' named entity 'FOLLOWING' named entity '50%' named entity '090' named entity 'MODEL OF' named entity 'RECENTLY' named entity 'PATHOGENIC' named entity 'MEASURABLE' named entity 'TO PROVIDE' named entity 'DURABILITY' named entity 'IMMUNITY' named entity 'CORRELATED' named entity 'EXPRESSED' named entity 'PLACE' named entity 'HANTAVIRUS' named entity 'EXPOSURE' named entity '28G' named entity 'SINGLE' named entity 'DECREASE' named entity 'MONTHS' named entity 'IMMUNE RESPONSE' named entity 'ROBUST' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'ANDES VIRUS' named entity 'VACCINE' named entity 'ADMINISTERED' named entity 'DAYS' named entity 'BASED' named entity 'THERAPIES' named entity 'HIGHLY' named entity 'ETIOLOGIC AGENT' named entity 'REPLICATION' named entity 'SCHEDULE' named entity 'GLYCOPROTEIN' named entity 'COMPETENT'

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