About: Neurovirulence Properties of Recombinant Vesicular Stomatitis Virus Vectors in Non-Human Primates

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About: Neurovirulence Properties of Recombinant Vesicular Stomatitis Virus Vectors in Non-Human Primates Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neurovirulence Properties of Recombinant Vesicular Stomatitis Virus Vectors in Non-Human Primates
Creator	Nasar, Farooq Draper, Kenneth Javadian, Ali Lee, Margaret Clarke, David Coleman, John Johnson, J Michael Hendry, R Price, Roger Reilly, Patricia Udem, Stephen
Source	Elsevier; Medline; PMC
abstract	Although vesicular stomatitis virus (VSV) neurovirulence and pathogenicity in rodents have been well studied, little is known about VSV pathogenicity in non-human primates. To address this question, we measured VSV viremia, shedding, and neurovirulence in macaques. Following intranasal inoculation, macaques shed minimal recombinant VSV (rVSV) in nasal washes for one day post-inoculation; viremia was not detected. Following intranasal inoculation of macaques, wild type (wt) VSV, rVSV, and two rVSV-HIV vectors showed no evidence of spread to CNS tissues. However, macaques inoculated intrathalamically with wt VSV developed severe neurological disease. One of four macaques receiving rVSV developed clinical and histological signs similar to the wt group, while the remaining three macaques in this group and all of the macaques in the rVSV-HIV vector groups showed no clinical signs of disease and reduced severity of histopathology compared to the wt group. The implications of these findings for rVSV vaccine development are discussed.
has issue date	2007-03-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2006.10.026
bibo:pmid	17098273
has license	green-oa
sha1sum (hex)	228d198944088138adf063f7a17c3a55f47bbb39
schema:url	https://doi.org/10.1016/j.virol.2006.10.026
resource representing a document's title	Neurovirulence Properties of Recombinant Vesicular Stomatitis Virus Vectors in Non-Human Primates
has PubMed Central identifier	PMC1865117
has PubMed identifier	17098273
schema:publication	Virology
resource representing a document's body	covid:228d198944088138adf063f7a17c3a55f47bbb39#body_text
is schema:about of	named entity 'neurological disease' named entity 'macaques' named entity 'neurovirulence' named entity 'group' named entity 'PRIMATES' named entity 'PATHOGENICITY' named entity 'DISEASE' named entity 'ABOUT' named entity 'MACAQUES' named entity 'PRIMATES' named entity 'ONE OF' named entity 'VECTORS' named entity 'NO CLINICAL SIGNS' named entity 'REDUCED' named entity 'SEVERE' named entity 'COMPARED' named entity 'SEVERITY' named entity 'ADDRESS' named entity 'NO EVIDENCE OF' named entity 'SIGNS' named entity 'VACCINE DEVELOPMENT' named entity 'LITTLE' named entity 'QUESTION' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'HAVE' named entity 'SIMILAR' named entity 'KNOWN' named entity '1 DAY' named entity 'PROPERTIES' named entity 'NON-' named entity 'FOLLOWING' named entity 'GROUPS' named entity 'HUMAN' named entity 'NEUROVIRULENCE' named entity 'HISTOPATHOLOGY' named entity 'VECTOR' named entity 'MINIMAL' named entity 'VECTORS' named entity 'TISSUES' named entity 'MEASURED' named entity 'CLINICAL' named entity 'HISTOLOGICAL' named entity 'NASAL' named entity 'INOCULATION' named entity 'RECEIVING' named entity 'NEUROLOGICAL DISEASE' named entity 'FINDINGS' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'RODENTS' named entity 'REMAINING' named entity 'THESE' named entity 'POST' named entity 'WILD TYPE' named entity 'NOT DETECTED' named entity 'VIREMIA' named entity 'NEUROVIRULENCE' named entity 'HIV' named entity 'GROUP' named entity 'RVSV' named entity 'HUMAN' named entity 'SPREAD' named entity 'CNS' named entity 'NON-' named entity 'RECOMBINANT' named entity 'RECOMBINANT' named entity 'INTRANASAL INOCULATION' named entity 'SHEDDING' covid:arg/228d198944088138adf063f7a17c3a55f47bbb39 named entity 'pathogenicity' named entity 'evidence' named entity 'neurovirulence'

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