About: Culture of Regulatory T‐Cell Lines from Bronchial Mucosa

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Culture of Regulatory T‐Cell Lines from Bronchial Mucosa
Creator	Thiel, Steffen Astrinidou-Vakaloudi, A Diamanti, I Georgakopoulou, E Hans, Reinholdt Hoffmann, Jürgen Jesper, Ralf Xatzidimitriou, D Xytsas, S
Source	PMC
abstract	T lymphocytes play a major role in many immune responses. In the last decade, special focus has been on the function of Th1 and Th2 effector cells. Now the importance of regulatory CD4(+)CD25(+) T cells in maintenance of the immunological homeostasis emerges. Sarcoidosis is a multisystem granulomatous disorder often affecting the lungs. The typical sarcoid granulomas consists of epitheloid cells, macrophages and lymphocytes, mainly CD4(+) T cells of Th1 phenotype. We have cultured T cells from bronchial biopsies of patients with sarcoidosis as well as from controls in high levels of interleukin 2 (IL‐2) and IL‐4 and demonstrate spontaneously arising CD4(+) CD25(+) populations and high concentrations of IL‐10 in these cultures. The main difference between cultures of sarcoid origin compared to controls is a very much higher concentration of the inflammatory cytokines IL‐6 and TNF‐α in cultures of sarcoid origin.
has issue date	2008-06-28(xsd:dateTime)
bibo:doi	10.1111/j.0300-9475.2004.01423z.x
has license	no-cc
sha1sum (hex)	226ab5769c42bf2415e5e8650d1043c7c6f6a057
schema:url	https://doi.org/10.1111/j.0300-9475.2004.01423z.x
resource representing a document's title	Culture of Regulatory T‐Cell Lines from Bronchial Mucosa
has PubMed Central identifier	PMC7169552
schema:publication	Scand J Immunol
resource representing a document's body	covid:226ab5769c42bf2415e5e8650d1043c7c6f6a057#body_text
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