About: The life cycle of SARS coronavirus in Vero E6 cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The life cycle of SARS coronavirus in Vero E6 cells
Creator	Jicheng, Huang Huanying, Zheng Jingqiang, Zhang Jinming, Cui Kunpeng, Li Ling, Fang Qinfen, Zhang Xiaojun, Huang
source	Medline; PMC
abstract	The aim of the study was to establish the life cycle of severe acute respiratory syndrome‐associated coronavirus (SARS CoV) in host cells and determine the pathogenesis of SARS. Vero E6 cells (African green monkey kidney cells) were inoculated with SARS coronavirus for 3, 7, 24, 48, and 72 hr, respectively, and were observed under electron microscope. It was found that the SARS coronavirus entered the cells through membrane fusion instead of endocytosis, and then the nucleocapsids assembled in the RER and matured by budding into the smooth vesicles, which were derived from the Golgi apparatus. The smooth vesicles fused with the cell membrane, and the mature particles were released. A special phenomenon was that some virus‐like particles appeared in the nucleus. We propose a scheme of the life cycle of SARS coronavirus and discuss the mechanism of its replication in Vero E6 cells. J. Med. Virol. 73:332–337, 2004. © 2004 Wiley‐Liss, Inc.
has issue date	2004-05-24(xsd:dateTime)
bibo:doi	10.1002/jmv.20095
bibo:pmid	15170625
has license	no-cc
sha1sum (hex)	22521011f224ab64de11ca25ab2dfb6fa6456cd6
schema:url	https://doi.org/10.1002/jmv.20095
resource representing a document's title	The life cycle of SARS coronavirus in Vero E6 cells
has PubMed Central identifier	PMC7166737
has PubMed identifier	15170625
schema:publication	J Med Virol
resource representing a document's body	covid:22521011f224ab64de11ca25ab2dfb6fa6456cd6#body_text
is schema:about of	named entity 'Golgi apparatus' named entity 'released' named entity 'cell membrane' named entity 'replication' named entity 'MEMBRANE FUSION' named entity 'DISCUSS' named entity 'MATURE' named entity 'PARTICLES' named entity 'DETERMINE' named entity 'CELLS' named entity 'SARS coronavirus' named entity 'African green monkey' named entity 'derived' named entity 'particles' named entity 'pathogenesis' named entity 'nucleocapsids' named entity 'endocytosis' named entity 'SARS coronavirus' named entity 'African green monkey kidney cells' named entity 'SARS CoV' named entity 'RER' named entity 'SARS' named entity 'Vero E6' named entity 'protein' named entity 'fetal bovine serum' named entity 'Invitrogen Corporation' named entity 'RER' named entity 'infection' named entity 'RER' named entity 'Vero E6' named entity 'RNA' named entity 'glycosylated' named entity 'nucleocapsids' named entity 'etiologically' named entity 'coronavirus' named entity 'immune electron microscopy' named entity 'morpho' named entity 'vesicles' named entity 'Golgi apparatus' named entity 'SARS coronavirus' named entity 'RER' named entity 'Vero E6' named entity 'nucleocapsids' named entity 'amino acids' named entity 'nucleus' named entity 'SARS coronavirus' named entity 'vesicles' named entity 'chymotrypsin' named entity 'electron microscopy' named entity 'infection' named entity 'Bombyx mori' named entity 'RER' named entity 'virions' named entity 'virus' named entity 'SARS-associated coronavirus' named entity 'coronavirus' named entity 'RER' named entity 'lysine' named entity 'nucleocapsids' named entity 'virus' named entity 'protein' named entity 'vesicles' named entity 'SARS coronavirus' named entity 'bud' named entity 'virus' named entity 'protein' named entity 'inoculated' named entity 'cell membrane' named entity 'nucleocapsids' named entity 'vesicles' named entity 'coronaviruses' named entity '229E' named entity 'coronavirus' named entity 'nuclear localization signal'

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