About: Hepatitis C virus exploits cyclophilin A to evade PKR

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Hepatitis C virus exploits cyclophilin A to evade PKR Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hepatitis C virus exploits cyclophilin A to evade PKR
Creator	Bartenschlager, Ralf Schoggins, John Towers, Greg Colpitts, Che Ng, Caitlin Ridewood, Sophie Schneiderman, Bethany Selwood, David Tabata, Keisuke Warne, Justin
Source	Medline; PMC
abstract	Counteracting innate immunity is essential for successful viral replication. Host cyclophilins (Cyps) have been implicated in viral evasion of host antiviral responses, although the mechanisms are still unclear. Here, we show that hepatitis C virus (HCV) co-opts the host protein CypA to aid evasion of antiviral responses dependent on the effector protein kinase R (PKR). Pharmacological inhibition of CypA rescues PKR from antagonism by HCV NS5A, leading to activation of an interferon regulatory factor-1 (IRF1)-driven cell intrinsic antiviral program that inhibits viral replication. These findings further the understanding of the complexity of Cyp-virus interactions, provide mechanistic insight into the remarkably broad antiviral spectrum of Cyp inhibitors, and uncover novel aspects of PKR activity and regulation. Collectively, our study identifies a novel antiviral mechanism that harnesses cellular antiviral immunity to suppress viral replication.
has issue date	2020-06-16(xsd:dateTime)
bibo:doi	10.7554/elife.52237
bibo:pmid	32539931
has license	cc-by
sha1sum (hex)	21fbeb50aa5917e3da6b6113009035900eb8882b
schema:url	https://doi.org/10.7554/elife.52237
resource representing a document's title	Hepatitis C virus exploits cyclophilin A to evade PKR
has PubMed Central identifier	PMC7297535
has PubMed identifier	32539931
schema:publication	eLife
resource representing a document's body	covid:21fbeb50aa5917e3da6b6113009035900eb8882b#body_text
is schema:about of	named entity 'immunity' named entity 'CypA' named entity 'innate' named entity 'protein' named entity 'kinase' named entity 'broad' named entity 'PKR' named entity 'provide' named entity 'harnesses' named entity 'spectrum' named entity 'hepatitis C virus' named entity 'regulation' named entity 'insight' named entity 'inhibits' named entity 'identifies' named entity 'Cyp' named entity 'viral replication' named entity 'Pharmacological' named entity 'protein' named entity 'antiviral' named entity 'PKR' named entity 'kinase' named entity 'antiviral' named entity 'effector protein' named entity 'cyclophilins' named entity 'viral replication' named entity 'DpnI' named entity 'IRF1' named entity 'Huh7' named entity 'PKR' named entity 'puromycin' named entity 'polymerase' named entity 'RIG-I' named entity 'RIG-I' named entity 'Feng Zhang' named entity 'IFN' named entity 'kinase' named entity 'HCV' named entity 'Huh7' named entity 'PKR' named entity 'HCV' named entity 'IRF1' named entity 'plasmid' named entity 'Huh7' named entity 'syringe' named entity 'Dehydrated' named entity 'streptomycin' named entity 'antiviral activity' named entity 'Huh7' named entity 'guide RNA' named entity 'IFN' named entity 'PKR' named entity 'antibodies' named entity 'Antibodies' named entity 'HCV' named entity 'hepatocyte' named entity 'HCV' named entity 'methanol' named entity 'PKR' named entity 'PKR' named entity 'primer' named entity 'Huh7' named entity 'IFN' named entity 'IRF1' named entity 'PBS' named entity 'Firefly luciferase' named entity 'clonal' named entity 'Flaviviridae' named entity 'NS3' named entity 'Zeocin' named entity 'Huh7' named entity 'CypA'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software