About: Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

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About: Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife
Creator	Jin, Xin Wang, Jian Liu, Zhongmin Xu, Yan Chen, Lei Li, Fang Chen, Fang Xiang, Rong Chen, Haixia Qiu, Wei Sun, Jian Yang, Huanming Zhu, Yixin Liu, Huan He, Qian Wang, Haoyu Wang, Xiaoling Hua, Yan Xu, Xun Han, Lei Lu, Haorong An, Fuyu Bao, Heng Chen, Dongsheng Cui, Zehua Ding, Peiwen Ding, Xiangning Fang, Dongming Feng, Weimin Jiang, Sanjie Kumar Sahu, Sunil Lan, Tianming Li, Haimeng Liu, Yahong Luo, Lihua Ma, Xiaoyan Qiu, Jiaying Sun, Xinghuai Sun, Chengcheng Wang, Feiyue Wang, Shiyou Wang, Xiran Wu, Jihong Wu, Weiying Wu, Wendi Wu, Yiquan Yuan, Yuting Zeng, Yuying Zhang, Le Zhang, Shenghai Zhu, Jiacheng Zhu, Linnan
Source	BioRxiv
abstract	A few animals have been suspected to be intermediate hosts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a large-scale single-cell screening of SARS-CoV-2 target cells on a wide variety of animals is missing. Here, we constructed the single-cell atlas for 11 representative species in pets, livestock, poultry, and wildlife. Notably, the proportion of SARS-CoV-2 target cells in cat was found considerably higher than other species we investigated and SARS-CoV-2 target cells were detected in multiple cell types of domestic pig, implying the necessity to carefully evaluate the risk of cats during the current COVID-19 pandemic and keep pigs under surveillance for the possibility of becoming intermediate hosts in future coronavirus outbreak. Furthermore, we screened the expression patterns of receptors for 144 viruses, resulting in a comprehensive atlas of virus target cells. Taken together, our work provides a novel and fundamental strategy to screen virus target cells and susceptible species, based on single-cell transcriptomes we generated for domesticated animals and wildlife, which could function as a valuable resource for controlling current pandemics and serve as an early warning system for coping with future infectious disease threats.
has issue date	2020-06-14(xsd:dateTime)
bibo:doi	10.1101/2020.06.13.149690
has license	biorxiv
sha1sum (hex)	21f445f1c48f64ce15101c9da9c046e0c0ad833d
schema:url	https://doi.org/10.1101/2020.06.13.149690
resource representing a document's title	Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife
schema:publication	bioRxiv
resource representing a document's body	covid:21f445f1c48f64ce15101c9da9c046e0c0ad833d#body_text
is schema:about of	named entity 'atlas' named entity 'single-cell' named entity 'transcriptomes' named entity 'possibility' named entity 'future' named entity 'livestock' named entity 'screening' named entity 'pigs' named entity 'target cells' named entity 'species' named entity 'target cells' named entity 'wide' named entity 'pets' named entity 'viruses' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'poultry' named entity 'virus' named entity 'SARS-CoV-2' named entity 'COVID-19 pandemic' named entity 'single-cell' named entity 'pig' named entity 'dog' named entity 'hamster' named entity 'TMPRSS2' named entity 'virus' named entity 'kidney' named entity 'pig' named entity 'pangolin' named entity 'pig' named entity 'chicken' named entity 'single cell' named entity 'SARS-CoV-2'

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