About: Expression of viral and myelin gene transcripts in a murine CNS demyelinating disease caused by a coronavirus

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About: Expression of viral and myelin gene transcripts in a murine CNS demyelinating disease caused by a coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Expression of viral and myelin gene transcripts in a murine CNS demyelinating disease caused by a coronavirus
Creator	Holmes, Kathryn Friedrich, Victor Cardellechio,', Christine Dubois-Dalcq1, Monique Godfraind, Jordan, Craig
Source	Medline; PMC
abstract	C57BI/6N mice develop a CNS demyelinating disease when inoculated intracranially at 4 weeks of age with the A59 strain of mouse hepatitis virus (MHV‐A59). In order to explore the virus‐host interactions, the histological features of the demyelinating disease were correlated with the spatial and temporal distribution of viral transcripts and the expression of oligodendrocyte‐specific genes (myelin basic protein, proteolipid protein, myelin‐associated glycoprotein, and 2′, 3′ cyclic nucleotide 3′‐phosphohydrolase) in the spinal cord of diseased mice. Three distinct phases in the disease were identified. In the first phase, 1 week postinfection (1 WPI), virus replication was widespread in both gray and white matter but was preferentially occurring in glial cells. In the ventral and dorsal root zones where viral transcripts were most abundant, all myelin gene transcripts were decreased before demyelination was seen. During the second phase of the disease (2–3 WPI), viral transcripts decreased in abundance and became restricted to the white matter. Numerous demyelinating lesions were observed and were characterized by inflammatory cells, paucity of oligodendrocytes, and a profound decrease of all myelin gene transcripts. In the third phase of the disease (4–6 WPI) no viral transcripts were detected, and remyelination began. In the lesions and the tissue surrounding them, transcripts of all myelin genes increased to levels above normal. The increased expression of myelin gene transcripts occurred in a synchronized manner and with a cellular distribution reminiscent of that seen in developmental myelination. These molecular events correlated with efficient remyelination and clinical recovery in this murine demyelinating disease.
has issue date	2004-10-12(xsd:dateTime)
bibo:doi	10.1002/glia.440020505
bibo:pmid	2478465
has license	no-cc
sha1sum (hex)	21c29b82b24ba74060c1434cf92099785cf28086
schema:url	https://doi.org/10.1002/glia.440020505
resource representing a document's title	Expression of viral and myelin gene transcripts in a murine CNS demyelinating disease caused by a coronavirus
has PubMed Central identifier	PMC7165873
has PubMed identifier	2478465
schema:publication	Glia
resource representing a document's body	covid:21c29b82b24ba74060c1434cf92099785cf28086#body_text
is schema:about of	named entity 'transcripts' named entity 'expression' named entity 'murine' named entity 'virus' named entity 'weeks' named entity 'Viral' named entity 'VIRAL' named entity 'PHOSPHOHYDROLASE' named entity 'AGE' named entity 'DISEASE' named entity 'DISTINCT' named entity 'DETECTED' named entity 'SEEN' named entity 'A59' named entity 'INCREASED EXPRESSION' named entity 'PROFOUND' named entity 'WPI' named entity 'CORRELATED' named entity 'THESE' named entity 'STRAIN' named entity 'VENTRAL' named entity 'age' named entity 'demyelination' named entity 'remyelination' named entity 'levels' named entity 'developmental' named entity 'myelin' named entity 'proteolipid protein' named entity 'transcripts' named entity 'inflammatory cells' named entity 'manner' named entity 'WPI' named entity 'demyelinating disease' named entity 'gene' named entity 'demyelinating disease' named entity 'cellular' named entity 'identified' named entity 'viral' named entity 'Disease' named entity 'demyelination' named entity 'virus' named entity 'remyelination' named entity 'inoculated' named entity 'spinal cord' named entity 'oligodendrocyte' named entity 'glial cells' named entity 'CNS' named entity 'myelin' named entity 'murine' named entity 'white matter' named entity 'Viral' named entity 'CNS' named entity 'Coronavirus' named entity 'Demyelinating Disease' named entity 'dorsal funiculus' named entity 'lipophilic' named entity 'myelin' named entity 'MAG' named entity 'clone' named entity 'MAG' named entity 'glial cells' named entity 'serum' named entity 'myelin sheaths' named entity 'inoculation' named entity 'MAG' named entity 'staining' named entity 'gelatin' named entity 'amino acids' named entity 'MAG' named entity 'MHV' named entity 'glial fibrillary acidic protein' named entity 'virus' named entity 'myelin' named entity 'demyelination' named entity 'oligodendrocytes' named entity 'staining'

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