About: Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects

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About: Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects
Creator	Su, Li Li, Yinghua Chen, Da-Gui Kong, De-Pei Tu, Ye Wang, Zhi-Bin Zhang, Chen-Xi Zhang, Wan-Nian Zhuang, Chun-Lin
source	BioRxiv
abstract	Coronavirus Disease 2019 (COVID-19) infected by Severe Acute Respiratory Syndrome Coronavirus −2 (SARS-CoV-2) has been declared a public health emergency of international concerns. Cytokine storm syndrome (CSS) is a critical clinical symptom of severe COVID-19 patients, and the macrophage is recognized as the direct host cell of SARS-CoV-2 and potential drivers of CSS. In the present study, peramivir was identified to reduce TNF-α by partly intervention of NF-κB activity in LPS-induced macrophage model. In vivo, peramivir reduced the multi-cytokines in serum and bronchoalveolar lavage fluid (BALF), alleviated the acute lung injury and prolonged the survival time in mice. In human peripheral blood mononuclear cells (hPBMCs), peramivir could also inhibit the release of TNF-α. Collectively, we proposed that peramivir might be a candidate for the treatment of COVID-19 and other infections related CSS. Graphic Abstract
has issue date	2020-07-14(xsd:dateTime)
bibo:doi	10.1101/2020.07.13.201806
has license	biorxiv
sha1sum (hex)	21ac35ec74d29ceec341966a309c6f54fe1c16be
schema:url	https://doi.org/10.1101/2020.07.13.201806
resource representing a document's title	Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects
schema:publication	bioRxiv
resource representing a document's body	covid:21ac35ec74d29ceec341966a309c6f54fe1c16be#body_text
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