About: Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

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About: Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis
Creator	Wang, Xin Yang, Xing Yin, Yue Zhu, Zhaoqin Wu, Ping Zhu, Tongyu Liang, Qiming Peng, Chao Fu, Joyce Guo, Mingquan Li, Jingjiao Liu, Chengrong Liu, Zhenshan Qu, Yafei Tian, Xiaoxu Xiao, Zixuan
source	BioRxiv
abstract	The ongoing coronavirus disease (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a global public health concern due to relatively easy person-to-person transmission and the current lack of effective antiviral therapy. However, the exact molecular mechanisms of SARS-CoV-2 pathogenesis remain largely unknown. We exploited an integrated proteomics approach to systematically investigate intra-viral and virus-host interactomes for the identification of unrealized SARS-CoV-2 host targets and participation of cellular proteins in the response to viral infection using peripheral blood mononuclear cells (PBMCs) isolated from COVID-19 patients. Using this approach, we elucidated 251 host proteins targeted by SARS-CoV-2 and more than 200 host proteins that are significantly perturbed in COVID-19 derived PBMCs. From the interactome, we further identified that non-structural protein nsp9 and nsp10 interact with NKRF, a NF-КB repressor, and may precipitate the strong IL-8/IL-6 mediated chemotaxis of neutrophils and overexuberant host inflammatory response observed in COVID-19 patients. Our integrative study not only presents a systematic examination of SARS-CoV-2-induced perturbation of host targets and cellular networks to reflect disease etiology, but also reveals insights into the mechanisms by which SARS-CoV-2 triggers cytokine storms and represents a powerful resource in the quest for therapeutic intervention.
has issue date	2020-04-02(xsd:dateTime)
bibo:doi	10.1101/2020.03.31.019216
has license	biorxiv
sha1sum (hex)	2170b29b2ea98d86e2d2f5160d577ff28f463138
schema:url	https://doi.org/10.1101/2020.03.31.019216
resource representing a document's title	Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis
schema:publication	bioRxiv
resource representing a document's body	covid:2170b29b2ea98d86e2d2f5160d577ff28f463138#body_text
is schema:about of	named entity 'caused' named entity 'SARS-CoV-2' named entity 'effective' named entity 'molecular mechanisms' named entity 'cellular proteins' named entity 'storms' named entity 'health concern' named entity 'remain' named entity 'peripheral blood mononuclear cells' named entity 'reflect' named entity 'proteins' named entity 'integrative' covid:arg/2170b29b2ea98d86e2d2f5160d577ff28f463138 named entity 'exploited' named entity 'strong' named entity 'precipitate' named entity 'COVID-19' named entity 'host' named entity 'systematically' named entity 'patients' named entity 'observed' named entity 'targets' named entity 'chemotaxis' named entity 'Our' named entity 'IL-8' named entity 'reveals' named entity 'host' named entity 'SARS-CoV-2' named entity 'repressor' named entity 'derived' named entity 'isolated' named entity 'pathogenesis' named entity 'NKRF' named entity 'NF-kB' named entity 'SARS-CoV-2' named entity 'COVID-19' named entity 'viral infection' named entity 'PBMCs' named entity 'COVID' named entity 'interact' named entity 'IL-8' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'Virus' named entity 'virulence factors' named entity 'pathogenesis' named entity 'Public Health' named entity 'structural proteins' named entity 'TCR' named entity 'signaling pathway' named entity 'nsp2' named entity 'airway' named entity 'UniProtKB' named entity 'JAK kinases' named entity 'IL-8' named entity 'transcriptional repressor' named entity 'IL-6' named entity 'virus replication' named entity 'neutrophil' named entity 'virulence factors' named entity 'protein' named entity 'Nsp3' named entity 'denaturing' named entity 'structural proteins' named entity 'SARS-CoV-2' named entity 'cytokine' named entity 'IL-8' named entity 'PSMD2' named entity 'HEK293 cells'

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