About: Antiviral effect of lithium chloride on porcine epidemic diarrhea virus in vitro

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral effect of lithium chloride on porcine epidemic diarrhea virus in vitro
Creator	Zhao, Jun Wang, Yong-Sheng Gao, Dong-Sheng Li, Hong-Jie Li, Yong-Tao Liu, Hong-Ying
Source	Elsevier; Medline; PMC
abstract	Abstract Porcine epidemic diarrhea virus (PEDV), a member of the Coronaviridae family, causes acute diarrhea, vomiting, dehydration, and high mortality rates in neonatal piglets. Severe outbreaks of PEDV variants have re-emerged in Asia and North America since 2010, causing tremendous economic losses to the swine industry. The lack of effective therapeutic treatment promotes the research for new antivirals. Lithium chloride (LiCl) has been reported as a potential antiviral drug for certain viruses. In this study, the antiviral effect of LiCl on PEDV in Vero cells was evaluated. Real-time quantitative PCR and indirect immunofluorescence assay indicated that LiCl effectively inhibited the entry and replication of PEDV in Vero cells. The expression of viral RNA and protein of PEDV in Vero cells was suppressed in a dose-dependent manner by LiCl. Moreover, addition of LiCl inhibited both early and late cell apoptosis induced by PEDV. Our data implied that LiCl could be a potential antiviral drug against PEDV infection. Further studies are required to explore the antiviral effect of lithium chloride on PEDV infection in vivo.
has issue date	2018-06-30(xsd:dateTime)
bibo:doi	10.1016/j.rvsc.2018.03.002
bibo:pmid	29547727
has license	els-covid
sha1sum (hex)	2144e51e8ee97ba0715d6e50306dd786daa63e79
schema:url	https://doi.org/10.1016/j.rvsc.2018.03.002
resource representing a document's title	Antiviral effect of lithium chloride on porcine epidemic diarrhea virus in vitro
has PubMed Central identifier	PMC7111825
has PubMed identifier	29547727
schema:publication	Research in Veterinary Science
resource representing a document's body	covid:2144e51e8ee97ba0715d6e50306dd786daa63e79#body_text
is schema:about of	named entity 'LITHIUM CHLORIDE' named entity 'quantitative PCR' named entity 'Coronaviridae' named entity 'evaluated' named entity 'Real-time' named entity 'Lithium chloride' named entity 'data' named entity 'acute' named entity 'EFFECT' named entity 'INDICATED' named entity 'ANTIVIRALS' named entity 'REPORTED' named entity 'INHIBITED' named entity 'REAL-TIME QUANTITATIVE PCR' named entity 'REQUIRED' named entity 'EARLY' named entity 'ANTIVIRAL DRUG' named entity 'VIRAL RNA' named entity 'VARIANTS' named entity 'VIRUSES' named entity 'IMMUNOFLUORESCENCE ASSAY' named entity 'APOPTOSIS' named entity 'ECONOMIC' named entity 'CAUSING' named entity 'DATA' named entity 'DOSE-DEPENDENT' named entity 'REPLICATION' named entity 'EVALUATED' covid:arg/2144e51e8ee97ba0715d6e50306dd786daa63e79 named entity 'VOMITING' named entity 'EFFECTIVE' named entity 'FAMILY' named entity 'EFFECT' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'IN VITRO' named entity 'CELL' named entity 'MEMBER OF' named entity 'RESEARCH' named entity 'HAVE' named entity 'NEW' named entity 'INFECTION' named entity 'LITHIUM CHLORIDE' named entity 'ACUTE DIARRHEA' named entity 'STUDY' named entity 'ASIA' named entity 'ANTIVIRAL' named entity 'OUTBREAKS' named entity 'DEHYDRATION' named entity 'EXPRESSION' named entity 'CERTAIN' named entity 'MORTALITY RATES' named entity 'ENTRY' named entity 'SUPPRESSED' named entity 'INDUSTRY' named entity 'CAUSES' named entity 'POTENTIAL' named entity 'ANTIVIRAL' named entity 'AND LATE' named entity 'SWINE' named entity 'S T' named entity 'CORONAVIRIDAE' named entity 'STUDIES' named entity 'INDIRECT IMMUNOFLUORESCENCE' named entity 'HIGH' named entity 'ADDITION' named entity 'LACK' named entity 'THERAPEUTIC' named entity 'NORTH AMERICA' named entity 'NEONATAL' named entity 'IN VIVO' named entity 'PROTEIN ' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'VERO CELLS' named entity 'SEVERE' named entity 'INDUCED' named entity 'OUR'

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