About: Determining the Provincial and National Burden of Influenza-Associated Severe Acute Respiratory Illness in South Africa Using a Rapid Assessment Methodology

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Determining the Provincial and National Burden of Influenza-Associated Severe Acute Respiratory Illness in South Africa Using a Rapid Assessment Methodology
Creator	Tempia, Stefano Feikin, Daniel Cohen, Cheryl Walaza, Sibongile Dawood, Halima Kahn, Kathleen Variava, Ebrahim Cohen, Adam Murray, Jillian Groome, Michelle Madhi, Shabir Tshangela, Akhona Venter, Marietje
Source	PMC
abstract	Local disease burden data are necessary to set national influenza vaccination policy. In 2010 the population of South Africa was 50 million and the HIV prevalence was 11%. We used a previously developed methodology to determine severe influenza burden in South Africa. Hospitalized severe acute respiratory illness (SARI) incidence was calculated, stratified by HIV status, for four age groups using data from population-based surveillance in one site situated in Gauteng Province for 2009–2011. These rates were adjusted for each of the remaining 8 provinces based on their prevalence of risk factors for pneumonia and healthcare-seeking behavior. We estimated non-hospitalized influenza-associated SARI from healthcare utilization surveys at two sites and used the percent of SARI cases positive for influenza from sentinel surveillance to derive the influenza-associated SARI rate. We applied rates of hospitalized and non-hospitalized influenza-associated SARI to census data to calculate the national number of cases. The percent of SARI cases that tested positive for influenza ranged from 7–17% depending on age group, year, province and HIV status. In 2010, there were an estimated 21,555 total severe influenza cases in HIV-uninfected individuals and 13,876 in HIV-infected individuals. In 2011, there were an estimated 29,892 total severe influenza cases in HIV-uninfected individuals and 17,289 in HIV-infected individuals. The incidence of influenza-associated SARI was highest in children <5 years and was higher in HIV-infected than HIV-uninfected persons in all age groups. Influenza virus was associated with a substantial amount of severe disease, especially in young children and HIV-infected populations in South Africa.
has issue date	2015-07-08(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0132078
bibo:pmid	26154306
has license	cc0
sha1sum (hex)	21133fab598928cee990ee06d660b1d00f317175
schema:url	https://doi.org/10.1371/journal.pone.0132078
resource representing a document's title	Determining the Provincial and National Burden of Influenza-Associated Severe Acute Respiratory Illness in South Africa Using a Rapid Assessment Methodology
has PubMed Central identifier	PMC4496064
has PubMed identifier	26154306
schema:publication	PLoS One
resource representing a document's body	covid:21133fab598928cee990ee06d660b1d00f317175#body_text
is schema:about of	named entity 'SOUTH AFRICA' named entity 'DETERMINE' named entity 'LOCAL DISEASE' named entity 'ACUTE RESPIRATORY ILLNESS' named entity 'SOUTH AFRICA' named entity 'SEVERE' named entity 'BURDEN' named entity 'DATA' named entity 'INFLUENZA' named entity 'SEVERE' named entity 'METHODOLOGY' named entity 'USED' named entity 'USING' named entity 'RAPID ASSESSMENT' named entity 'METHODOLOGY' named entity 'HIV' named entity 'MILLION' named entity 'POLICY' named entity 'INFLUENZA VACCINATION' named entity 'NATIONAL' named entity 'PREVIOUSLY' named entity 'PREVALENCE' named entity 'POPULATION' named entity 'NECESSARY' named entity 'SET' named entity 'ASSOCIATED' covid:arg/21133fab598928cee990ee06d660b1d00f317175 named entity 'influenza vaccination' named entity 'South Africa' named entity 'influenza' named entity 'Gauteng' named entity 'influenza' named entity 'pregnant women' named entity 'Soweto' named entity 'HIV' named entity 'Risk factors' named entity 'HIV' named entity 'private medical insurance' named entity 'pneumonia' named entity 'influenza' named entity 'HIV' named entity 'LRTI' named entity 'HIV' named entity 'SARI' named entity 'Eastern Cape' named entity 'South Africa' named entity 'HIV' named entity 'influenza' named entity 'HIV' named entity 'Gauteng Province' named entity 'Guatemala' named entity 'influenza' named entity 'Chris Hani Baragwanath Academic Hospital' named entity 'cough' named entity 'South Africa' named entity 'HIV' named entity 'Gauteng' named entity 'Gauteng' named entity 'influenza' named entity 'Demographic and Health Survey' named entity 'HIV' named entity 'influenza' named entity 'exclusive breastfeeding' named entity 'Gauteng' named entity 'Chris Hani Baragwanath Academic Hospital' named entity 'incidence rate' named entity 'sore throat' named entity 'HIV' named entity 'CHBAH'

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