About: Interleukin-18 expression and the response to treatment in patients with psoriasis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interleukin-18 expression and the response to treatment in patients with psoriasis
Creator	Ismail, Somaia Mikhael, Nancy Rasmy, Hanaa
topic	covid:20dd62d0387e8b4231d67af2eaf757767492656e#this
Source	Medline; PMC
abstract	INTRODUCTION: The aim of the study was to demonstrate interleukin-18 (IL-18) expression in keratinocytes from psoriatic lesions in comparison to keratinocytes from uninvolved skin and to study the change of expression after therapeutic interventions. MATERIAL AND METHODS: This study included 16 patients of different clinical subtypes of psoriasis. Interleukin-18 gene expression analysis was performed using real time quantitative PCR. Three biopsies were obtained from each patient. Two were taken from the lesional psoriatic skin and from uninvolved skin before starting treatment. A third lesional skin biopsy was taken at the end of 2 months of treatment. The treatment was in the form of topical steroids or oral systemic methotrexate. RESULTS: Of all 16 studied patients, significantly increased IL-18 expression was noted in keratinocytes from psoriatic lesions before and after treatment when compared to keratinocytes from uninvolved skin (p = 0.001 and p = 0.002 respectively). The IL-18 expression in the skin lesions after treatment was significantly lower than lesional skin before treatment (p = 0.023). In psoriatic skin lesions of all studied patients IL-18 expression was significantly correlated with disease duration (r = 0.40 and p = 0.01) and clinical severity of psoriasis (r = 0.72 and p = 0.001). CONCLUSIONS: Increased IL-18 expression in keratinocytes from psoriatic lesions of our patients and its correlation with disease duration and severity supported the concept of psoriasis as a T cell mediated autoimmune disease. This could establish therapeutic and preventive approaches for psoriasis that ultimately lead to improved outcomes for patients.
has issue date	2011-09-02(xsd:dateTime)
bibo:doi	10.5114/aoms.2011.24144
bibo:pmid	22291810
has license	cc-by-nc-nd
sha1sum (hex)	20dd62d0387e8b4231d67af2eaf757767492656e
schema:url	https://doi.org/10.5114/aoms.2011.24144
resource representing a document's title	Interleukin-18 expression and the response to treatment in patients with psoriasis
has PubMed Central identifier	PMC3258774
has PubMed identifier	22291810
schema:publication	Arch Med Sci
resource representing a document's body	covid:20dd62d0387e8b4231d67af2eaf757767492656e#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/20dd62d0387e8b4231d67af2eaf757767492656e
is schema:about of	named entity 'DISEASE DURATION' named entity 'SKIN BIOPSY' named entity 'THERAPEUTIC' named entity 'FORM' named entity 'CORRELATED' named entity '0.01' named entity 'AT THE END' named entity 'AIM' named entity 'THERAPEUTIC INTERVENTIONS' named entity 'CORRELATION' named entity 'SYSTEMIC' named entity 'EXPRESSION' named entity 'MEDIATED' named entity 'LOWER' named entity 'CONCLUSIONS' named entity 'COMPARISON' named entity 'UNINVOLVED' named entity 'AUTOIMMUNE DISEASE' named entity 'NOTED' named entity 'THE CHANGE' named entity 'STEROIDS' named entity 'PERFORMED' named entity 'keratinocytes' named entity 'aim' named entity 'correlated' named entity 'Results' named entity 'This' named entity 'lesions' named entity 'oral' named entity 'expression' named entity 'PSORIASIS' named entity 'RESULTS' named entity 'IL-18' named entity 'PATIENTS' named entity 'ESTABLISH' named entity 'SKIN LESIONS' named entity 'CLINICAL' named entity 'OUR' named entity 'OBTAINED' named entity 'T CELL' named entity 'REAL TIME QUANTITATIVE PCR' named entity 'METHOTREXATE' named entity 'OUTCOMES' named entity 'INTERLEUKIN-18' named entity 'METHODS' named entity 'EXPRESSION' named entity 'RESPONSE TO TREATMENT' named entity 'INCREASED' named entity 'ITS' named entity 'INCLUDED' named entity 'CONCEPT' named entity 'PATIENT' named entity 'USING' named entity 'KERATINOCYTES' named entity '0.72' named entity 'AFTER TREATMENT' named entity 'TREATMENT' named entity 'STUDY' named entity 'PATIENTS' named entity 'SUPPORTED' named entity 'DIFFERENT' named entity 'GENE EXPRESSION ANALYSIS' named entity 'APPROACHES' named entity 'LESIONS' named entity '28P' named entity 'STARTING' named entity 'INTERLEUKIN-18' named entity '0.001' named entity 'BIOPSIES' named entity 'TOPICAL' named entity 'PREVENTIVE' named entity 'SKIN' named entity 'SEVERITY' named entity 'INTRODUCTION' named entity 'SUBTYPES' named entity 'MATERIAL' named entity 'A T'

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