About: Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity

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About: Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity
Creator	Aideyan, Letisha Avadhanula, Vasanthi Mehta, Reena Mei, Minghua Scheffler, Margaret Tapia, Lorena Jewell, Alan Piedra, Pedro Garofalo, Roberto Patel, Kirtida
source	Medline; PMC
abstract	BACKGROUND: Bronchiolitis is the leading cause of hospitalization in infants. Biomarkers of disease severity might help in clinical management. OBJECTIVE: To determine the clinical predictiveness of NW-LDH, NW-caspase 3/7, and NW-LDH/NW-caspase 3/7 ratio in bronchiolitis. METHODS: Previously healthy children less than 24 months of age with bronchiolitis were recruited from the Texas Children's emergency room and intensive care unit from October 2010 to April 2011. Demographic, clinical information, and NW samples were obtained at enrollment. NW samples were analyzed for respiratory viruses, caspase 3/7, and LDH. RESULTS: A viral pathogen was detected in 91·6% of 131 children, with the most common being respiratory syncytial virus and human rhinovirus. A single infection was found in 61·8% of subjects and co-infection in 29·8%. Children admitted to ICU had significantly higher NW-LDH than children sent home from the ER or admitted to the general floor (P = 0·02). Children infected with RSV had the highest NW-LDH concentration (P = 0·03) compared with other viral infections. NW-LDH and NW-caspase were significantly correlated (r = 0·77, P < 0·0001). The univariate models showed NW-LDH and NW-LDH/NW- caspase 3/7 ratio were directly associated with hospitalization. Mutivariate regression analyses suggested a complex interaction between the biomarkers, demographics, and disposition. CONCLUSIONS: NW-LDH, NW-caspase 3/7 and NW-LDH/NW-caspase 3/7 ratio and their interactions with demographic factors are predictive of bronchiolitis severity and can help distinguish children requiring ICU-level care from those admitted to the general floor, or discharged home from the emergency center.
has issue date	2014-08-12(xsd:dateTime)
bibo:doi	10.1111/irv.12276
bibo:pmid	25132512
has license	cc-by
sha1sum (hex)	20c5f4025a94ca3a48d6d8a23a9db2ebc8b5ec03
schema:url	https://doi.org/10.1111/irv.12276
resource representing a document's title	Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity
has PubMed Central identifier	PMC4262276
has PubMed identifier	25132512
schema:publication	Influenza Other Respir Viruses
resource representing a document's body	covid:20c5f4025a94ca3a48d6d8a23a9db2ebc8b5ec03#body_text
is schema:about of	covid:arg/20c5f4025a94ca3a48d6d8a23a9db2ebc8b5ec03 named entity 'infants' named entity 'clinical management' named entity 'Bronchiolitis' named entity 'Bronchiolitis' named entity 'Lactate dehydrogenase' named entity 'bronchiolitis' named entity 'caspase 3' named entity 'clinical diagnosis' named entity 'Fisher's exact test' named entity 'LDH' named entity 'caspase 3' named entity 'Baylor College of Medicine' named entity 'descriptive statistics' named entity 'caspase 3' named entity 'severe respiratory failure' named entity 'dynamic range' named entity 'emergency department' named entity 'LDH' named entity 'risk factors' named entity 'infection' named entity 'caspase 3' named entity 'LDH' named entity 'log10' named entity 'Hispanic' named entity 'bronchiolitis' named entity 'apoptosis' named entity 'LDH' named entity 'secretory IgA' named entity 'enzyme' named entity 'LDH' named entity 'apoptosis' named entity 'lower respiratory tract' named entity 'caspase' named entity 'range of values' named entity 'caspase' named entity 'virus' named entity 'caspase 3' named entity 'aspirating' named entity 'logistic regression' named entity 'biomarkers' named entity 'Caspase 3' named entity 'bronchiolitis' named entity 'ventilatory support' named entity 'caspases' named entity 'medical attention' named entity 'viruses' named entity 'Roche Applied Science' named entity 'caspase 3' named entity 'RSV' named entity 'primers' named entity 'caspase-3' named entity 'neuromuscular disease' named entity 'wheezing' named entity 'oxygen therapy' named entity 'Bronchiolitis' named entity 'apoptotic' named entity 'immune response' named entity 'viral infection' named entity 'coronaviruses' named entity 'RSV' named entity 'breastfeeding' named entity 'caspase 3' named entity 'LDH' named entity 'caspase 3' named entity 'Texas Children's Hospital' named entity 'caspase 3' named entity 'LDH' named entity 'LDH' named entity 'recombinant' named entity 'bronchiolitis' named entity 'viruses'

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