About: The nucleolar protein GLTSCR2 is required for efficient viral replication

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About: The nucleolar protein GLTSCR2 is required for efficient viral replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The nucleolar protein GLTSCR2 is required for efficient viral replication
Creator	Wang, Peng Han, Shi-Chong Li, Cui-Cui Meng, Wen Wang, Xiao-Jia Wang, Xiao-Jun
Source	Medline; PMC
abstract	Glioma tumor suppressor candidate region gene 2 protein (GLTSCR2) is a nucleolar protein. In the investigation of the role of GLTSCR2 that played in the cellular innate immune response to viral infection, we found GLTSCR2 supported viral replication of rhabdovirus, paramyxovirus, and coronavirus in cells. Viral infection induced translocation of GLTSCR2 from nucleus to cytoplasm that enabled GLTSCR2 to attenuate type I interferon IFN-β and support viral replication. Cytoplasmic GLTSCR2 was able to interact with retinoic acid-inducible gene I (RIG-I) and the ubiquitin-specific protease 15 (USP15), and the triple interaction induced USP15 activity to remove K63-linked ubiquitination of RIG-I, leading to attenuation of RIG-I and IFN-β. Blocking cytoplasmic translocation of GLTSCR2, by deletion of its nuclear export sequence (NES), abrogated its ability to attenuate IFN-β and support viral replication. GLTSCR2-mediated attenuation of RIG-I and IFN-β led to alleviation of host cell innate immune response to viral infection. Our findings suggested that GLTSCR2 contributed to efficient viral replication, and GLTSCR2 should be considered as a potential target for therapeutic control of viral infection.
has issue date	2016-11-08(xsd:dateTime)
bibo:doi	10.1038/srep36226
bibo:pmid	27824081
has license	cc-by
sha1sum (hex)	20af160641510a4c79b9a23b06ea83d27ebba059
schema:url	https://doi.org/10.1038/srep36226
resource representing a document's title	The nucleolar protein GLTSCR2 is required for efficient viral replication
has PubMed Central identifier	PMC5099953
has PubMed identifier	27824081
schema:publication	Sci Rep
resource representing a document's body	covid:20af160641510a4c79b9a23b06ea83d27ebba059#body_text
is schema:about of	named entity 'paramyxovirus' named entity 'ubiquitination' named entity 'cytoplasm' named entity 'NUCLEOLAR' named entity 'POTENTIAL' named entity 'LED' named entity 'RHABDOVIRUS' named entity 'THERAPEUTIC' named entity 'INTERACTION' named entity 'EFFICIENT' named entity 'GENE' named entity 'SUPPORT' named entity 'LEADING' named entity 'INFECTION INDUCED' named entity 'UBIQUITINATION' named entity 'RESPONSE TO' named entity 'CYTOPLASMIC' named entity 'USP15' named entity 'ENABLED' named entity 'BLOCKING' named entity 'CYTOPLASM' named entity 'TO INTERACT WITH' named entity 'MEDIATED' named entity 'HOST CELL' named entity 'ATTENUATE' named entity 'GLTSCR2' named entity 'TRIPLE' named entity 'OUR' named entity 'VIRAL REPLICATION' named entity 'INDUCED' named entity 'VIRAL INFECTION' named entity 'IFN' named entity 'TARGET' named entity 'NUCLEUS' named entity 'TYPE I INTERFERON' covid:arg/20af160641510a4c79b9a23b06ea83d27ebba059 named entity 'INDUCIBLE' named entity 'REQUIRED' named entity 'OPEN' named entity 'FINDINGS' named entity 'CELLS' named entity 'PLAYED' named entity 'DELETION' named entity 'TO REMOVE' named entity 'UBIQUITIN-SPECIFIC PROTEASE 15' named entity 'TRANSLOCATION' named entity 'RIG-I' named entity 'INNATE IMMUNE RESPONSE' named entity 'CELLULAR' named entity 'INTERFERON ' named entity 'INVESTIGATION' named entity 'ATTENUATION' named entity 'SUPPORTED' named entity 'EFFICIENT' named entity 'PROTEIN GLTSCR2' named entity 'ACTIVITY' named entity 'NUCLEAR EXPORT' named entity 'CONSIDERED' named entity 'CORONAVIRUS' named entity 'RETINOIC ACID' named entity 'ROLE' named entity 'FOUND' named entity 'K63' named entity 'VIRAL REPLICATION' named entity 'CONTROL' named entity 'PARAMYXOVIRUS' named entity 'ITS' named entity 'SEQUENCE' named entity 'RIG-I' named entity 'Viral infection' named entity 'IFN-β' named entity 'attenuate' named entity 'translocation' named entity 'suggested' named entity 'Cytoplasmic' named entity 'potential'

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