About: The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology

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About: The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology
Creator	Desforges, Marc Le Coupanec, Alain Dubois, Guillaume Talbot, Pierre Stodola, Jenny
Source	Elsevier; Medline; PMC
abstract	The OC43 strain of human coronavirus (HCoV-OC43) is an ubiquitous respiratory tract pathogen possessing neurotropic capacities. Coronavirus structural envelope (E) protein possesses specific motifs involved in protein-protein interaction or in homo-oligomeric ion channel formation, which are known to play various roles including in virion morphology/assembly and in cell response to infection and/or virulence. Making use of recombinant viruses either devoid of the E protein or harboring mutations either in putative transmembrane domain or PDZ-binding motif, we demonstrated that a fully functional HCoV-OC43 E protein is first needed for optimal production of recombinant infectious viruses. Furthermore, HCoV-OC43 infection of human epithelial and neuronal cell lines, of mixed murine primary cultures from the central nervous system and of mouse central nervous system showed that the E protein is critical for efficient and optimal virus replication and propagation, and thereby for neurovirulence.
has issue date	2017-12-26(xsd:dateTime)
bibo:doi	10.1016/j.virol.2017.12.023
bibo:pmid	29287230
has license	no-cc
sha1sum (hex)	201e6b41ce9154b6740c2ea4bbb5c7d9702a1987
schema:url	https://doi.org/10.1016/j.virol.2017.12.023
resource representing a document's title	The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology
has PubMed Central identifier	PMC7118982
has PubMed identifier	29287230
schema:publication	Virology
resource representing a document's body	covid:201e6b41ce9154b6740c2ea4bbb5c7d9702a1987#body_text
is schema:about of	named entity 'VIRUS PRODUCTION' named entity 'OC43' named entity 'morphology' named entity 'mutations' named entity 'optimal' named entity 'OC43' named entity 'PROTEIN ' named entity 'EFFICIENT' named entity 'PROTEIN ' named entity 'FORMATION' named entity 'RESPONSE TO' named entity 'SPECIFIC' named entity 'FUNCTIONAL' named entity 'MUTATIONS' named entity 'VIRULENCE' named entity 'PROPAGATION' named entity 'HUMAN' named entity 'ION CHANNEL' named entity 'TRANSMEMBRANE DOMAIN' named entity 'PRODUCTION' named entity 'POSSESSES' named entity 'OPTIMAL' named entity 'MOTIFS' named entity 'MURINE' named entity 'CELLS' named entity 'PROPAGATION' named entity 'HUMAN CORONAVIRUS' named entity 'HARBORING' named entity 'INCLUDING' named entity 'OC43' named entity 'NEURONAL' named entity 'PATHOLOGY' named entity 'DETERMINANT' named entity 'CNS' named entity 'INFECTIOUS' named entity 'CRITICAL' named entity 'IS A' named entity 'NEUROVIRULENCE' named entity 'ENVELOPE PROTEIN' named entity 'VIRUS REPLICATION' named entity 'VARIOUS' named entity 'CELL RESPONSE' named entity 'STRAIN' named entity 'PATHOGEN' named entity 'MORPHOLOGY' named entity 'VIRUSES' named entity 'NEUROTROPIC' named entity 'HCOV-OC43' named entity 'MIXED' named entity 'KNOWN' named entity 'INFECTION' named entity 'CELL LINES' named entity 'MOTIF' named entity 'ROLES' named entity 'INVOLVED' named entity 'BINDING' named entity 'FULLY' named entity 'PLAY' named entity 'HUMAN CORONAVIRUS' named entity 'NEUROVIRULENCE' named entity 'PDZ' named entity 'INTERACTION' named entity 'NEEDED' named entity 'E PROTEIN' named entity 'NEURONAL CELL' named entity 'UBIQUITOUS' named entity 'VIRION' named entity 'PRIMARY CULTURES' named entity 'MOUSE CENTRAL NERVOUS SYSTEM' named entity 'CRITICAL' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'STRUCTURAL' named entity 'ENVELOPE' named entity 'EPITHELIAL' named entity 'INFECTIOUS' named entity 'USE OF' named entity 'RECOMBINANT'

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