About: Bovine Herpesvirus 1 Counteracts Immune Responses and Immune-Surveillance to Enhance Pathogenesis and Virus Transmission

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bovine Herpesvirus 1 Counteracts Immune Responses and Immune-Surveillance to Enhance Pathogenesis and Virus Transmission
Creator	Jones, Clinton Ghiasi, Homayon Dix, Richard Forrest, James Suvas, Susmit
Source	PMC
abstract	Infection of cattle by bovine herpesvirus 1 (BoHV-1) can culminate in upper respiratory tract disorders, conjunctivitis, or genital disorders. Infection also consistently leads to transient immune-suppression. BoHV-1 is the number one infectious agent in cattle that is associated with abortions in cattle. BoHV-1, as other α-herpesvirinae subfamily members, establishes latency in sensory neurons. Stressful stimuli, mimicked by the synthetic corticosteroid dexamethasone, consistently induce reactivation from latency in latently infected calves and rabbits. Increased corticosteroid levels due to stress have a two-pronged effect on reactivation from latency by: (1) directly stimulating viral gene expression and replication, and (2) impairing antiviral immune responses, thus enhancing virus spread and transmission. BoHV-1 encodes several proteins, bICP0, bICP27, gG, UL49.5, and VP8, which interfere with key antiviral innate immune responses in the absence of other viral genes. Furthermore, the ability of BoHV-1 to infect lymphocytes and induce apoptosis, in particular CD4+ T cells, has negative impacts on immune responses during acute infection. BoHV-1 induced immune-suppression can initiate the poly-microbial disorder known as bovine respiratory disease complex, which costs the US cattle industry more than one billion dollars annually. Furthermore, interfering with antiviral responses may promote viral spread to ovaries and the developing fetus, thus enhancing reproductive issues associated with BoHV-1 infection of cows or pregnant cows. The focus of this review is to describe the known mechanisms, direct and indirect, by which BoHV-1 interferes with antiviral immune responses during the course of infection.
has issue date	2019-05-07(xsd:dateTime)
bibo:doi	10.3389/fimmu.2019.01008
bibo:pmid	31134079
has license	cc-by
sha1sum (hex)	2005ffa70562f5f03b57f0d19f4d63e807762964
schema:url	https://doi.org/10.3389/fimmu.2019.01008
resource representing a document's title	Bovine Herpesvirus 1 Counteracts Immune Responses and Immune-Surveillance to Enhance Pathogenesis and Virus Transmission
has PubMed Central identifier	PMC6514135
has PubMed identifier	31134079
schema:publication	Front Immunol
resource representing a document's body	covid:2005ffa70562f5f03b57f0d19f4d63e807762964#body_text
is schema:about of	named entity 'Bovine' named entity 'Transmission' named entity 'MINI' named entity 'REVIEW' named entity 'PATHOGENESIS' named entity 'MINI' named entity 'IMMUNE RESPONSES' named entity 'IMMUNE' named entity 'VIRUS' named entity 'TRANSMISSION' named entity 'SURVEILLANCE' named entity 'BOVINE HERPESVIRUS 1' named entity 'ENHANCE' named entity 'Herpesvirus' named entity 'Bovine Herpesvirus 1' named entity 'Pathogenesis' named entity 'Virus Transmission' named entity 'ISRE' named entity 'cell-mediated immunity' named entity 'IFN' named entity 'IRF3' named entity 'mucosal surface' named entity 'late proteins' named entity 'antiviral' named entity 'latently infected' named entity '1.1' named entity 'cell to cell' named entity 'E3 ubiquitin ligase' named entity 'wild-type' named entity 'Cytotoxic T cell' named entity 'high levels' named entity 'IFN-β' named entity 'antigen processing' named entity 'virus' named entity 'trigeminal ganglia' named entity 'transcriptional activation' named entity 'Acute infection' named entity 'live vaccines' named entity 'HSV-1 infection' named entity 'micro-RNAs' named entity 'cultured cells' named entity 'IFN-γ receptor' named entity 'infection' named entity 'acute infection' named entity 'TBK1' named entity 'pathogenesis' named entity '49, 50' named entity 'pneumonia' named entity 'IFN-β' named entity 'mucosal surfaces' named entity 'Jak1' named entity 'Signal transducer' named entity 'VP8' named entity 'chemokines' named entity 'transactivation' named entity 'Denmark' named entity 'VP16' named entity 'IFN-β' named entity 'Serological testing' named entity 'IKK' named entity 'virus' named entity '19, 20' named entity 'peripheral nervous' named entity 'KLF15' named entity 'heifers' named entity 'gene' named entity 'transactivators' named entity 'IRF7' named entity 'IFN-γ' named entity 'proteasome' named entity 'mRNA expression' named entity 'incubation period' named entity 'JNK' named entity 'protein' named entity 'respiratory disease' named entity 'membrane-bound' named entity 'apoptosis'

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